{"id":75,"date":"2024-07-10T01:22:05","date_gmt":"2024-07-10T01:22:05","guid":{"rendered":"https:\/\/uchidalab.hiroshima-u.ac.jp\/?page_id=75"},"modified":"2026-04-09T00:26:27","modified_gmt":"2026-04-09T00:26:27","slug":"presentation","status":"publish","type":"page","link":"https:\/\/uchidalab.hiroshima-u.ac.jp\/index.php\/presentation\/","title":{"rendered":"\u7814\u7a76\u767a\u8868"},"content":{"rendered":"
\"\"<\/span>
English<\/span><\/div><\/a><\/div>\n\n

\u7814\u7a76\u767a\u8868<\/span><\/strong><\/p><\/div><\/div>

<\/div>

2025\u5e74\u5ea6<\/h2>

\u62db\u5f85<\/h2>
  1. \u6a4b\u672c \u6d0b\u4f51\u3000\u75be\u60a3\u8a98\u767a\u578bclaudin-5\u5909\u7570\u4f53\u306e\u540c\u5b9a\uff1a\u7d30\u80de\u9593\u9699\u30d0\u30ea\u30a2\u304b\u3089\u7d30\u80de\u9593\u9699\u30a2\u30cb\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u3078\u306e\u5909\u7570\u3000\u7b2c19\u56de\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u7814\u7a76\u4f1a\u5e74\u4f1a\u3000\u5ca1\u5c71\u30002025\u5e746\u67081\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
  2. Yosuke Hashimoto, Gerg\u0151 Porkol\u00e1b, Natalie Hudson, Jeffrey O’Callaghan, Nicole Hanley, Chris Greene, M\u00e1ria A. Deli, Matthew Identification of novel negative regulators of claudin-5 in vascular endothelial cells by genome-wide screening 7th Mini-symposium on the Blood-brain Barrier: From Basic to Clinical Research Seattle June 26-27,2025, Oral<\/li>\n\n
  3. Yasuo Uchida Next generation quantitative proteomics opens up the new fields of CNS barrier studies. The first knowledge exchange between Korean MPS engineers and Japanese barriologists  Hiroshima Oct 23-25, 2025 Oral\uff08English\uff09<\/li>\n\n
  4. Yosuke Hashimoto Pharmaceutical research focused on claudin-5 as  a barriologist The first knowledge exchange between Korean MPS engineers and Japanese barriologists  Hiroshima Oct 23-25, 2025 Oral\uff08English\uff09<\/li>\n\n
  5. \u5185\u7530 \u5eb7\u96c4\u3000\u4e2d\u67a2\u75be\u60a3\u306b\u304a\u3051\u308b\u85ac\u7269\u52d5\u614b\u30fb\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u306b\u5411\u3051\u305f\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u7814\u7a76\u30002025\u5e74\u5ea6 \u85ac\u7269\u52d5\u614b\u8ac7\u8a71\u4f1a 1\u6708\u4f8b\u4f1a\u3000\u6771\u4eac\u30002026\u5e741\u670830\u65e5\u3000\u62db\u5f85\u8b1b\u6f14<\/li>\n\n
  6. \u5185\u7530 \u5eb7\u96c4\u3000\u5275\u85ac\u3092\u52a0\u901f\u3055\u305b\u308b\u5e83\u5cf6\u5927\u5b66\u72ec\u81ea\u306e\u4f53\u5236\u3068\u6280\u8853\u3000\u5e83\u5cf6\u5927\u5b66\u304c\u8e8d\u52d5\u3057\u5e83\u5cf6\u306e\u5730\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u57fa\u91d1\u63a8\u9032\u4f1a \u7b2c8\u56de\u7dcf\u4f1a\u3000\u5e83\u5cf6\u30002026\u5e742\u67083\u65e5\u3000\u62db\u5f85\u8b1b\u6f14<\/li>\n\n
  7. \u5185\u7530 \u5eb7\u96c4\u3000\u4e2d\u67a2\u75be\u60a3\u5275\u85ac\u306b\u5411\u3051\u305f\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u7814\u7a76\u3000\u7530\u8fba\u30d5\u30a1\u30fc\u30de\u682a\u5f0f\u4f1a\u793e\u8b1b\u6f14\u4f1a\u3000\u6a2a\u6d5c\u4e8b\u696d\u6240\u30002026\u5e742\u67086\u65e5\u3000\u62db\u5f85\u8b1b\u6f14<\/li>\n\n
  8. Yosuke Hashimoto\u3000Research focused on an endothelial tight junction protein, Claudin-5\u3000\u7b2c103\u56de\u65e5\u672c\u751f\u7406\u5b66\u4f1a\u3000\u6771\u4eac\u30002026\u5e743\u670810\u65e5\u3000\u53e3\u982d\u767a\u8868\uff08\u82f1\u8a9e\uff09<\/li>\n\n
  9. Yosuke Hashimoto, Gerg\u0151 Porkol\u00e1b, Natalie Hudson, Chris Greene, Karine Poirier, Nathalie Boddaert, Arnold Munnich, Yasuo Uchida, Matthew Campbell\u3000CLDN5-related neurological disease\u30008th Mini-Symposium on the Blood\u2013Brain Barrier\u3000Szeged, Hungary\u3000March 26-28,2026 Oral(English)<\/li><\/ol>

    \u4e00\u822c <\/h2>
    1. \u5185\u7530 \u5eb7\u96c4\u3000\u591a\u69d8\u306a\u751f\u7269\u306b\u9069\u7528\u3067\u304d\u308b\u7db2\u7f85\u7684\u304b\u3064\u9ad8\u7cbe\u5ea6\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u30fb\u30ea\u30f3\u9178\u5316\u7d76\u5bfe\u5b9a\u91cf\u6cd5\u306e\u958b\u767a\u3000\u5b66\u8853\u5909\u9769\u9818\u57df\u7814\u7a76\uff08A\uff09\u300c\u6642\u9593\u30bf\u30f3\u30d1\u30af\u8cea\u5b66\u300d2025\u5e74\u5ea6 \u9818\u57df\u4f1a\u8b70\u3000\u6771\u4eac\u30002025\u5e744\u670817\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    2. \u5c71\u53e3 \u660e\u65e5\u7fd4\u3001\u9ad8\u7530 \u7be4\u6765\u3001\u5ddd\u898b \u660c\u53f2\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580P-gp\u3001BCRP\u3001OCT2\u3001MATE1 \u304a\u3088\u3073PEPT2\u306ein vivo\u6392\u51fa\u8f38\u9001\u6a5f\u80fd\u306e\u89e3\u660e\u3000\u7b2c19\u56de\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u7814\u7a76\u4f1a\u5e74\u4f1a\u3000\u5ca1\u5c71\u30002025\u5e746\u67081\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
    3. \u524d\u7530 \u7950\u5e0c\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u7af9\u6797 \u4f73\u5b50\u3001\u77f3\u5ddd \u82e5\u82b8\u3001\u5c71\u5d0e \u96c4\u3001\u6e05\u6c34 \u5b8f\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u4e38\u5c71 \u535a\u6587\u3001\u5ddd\u898b \u660c\u53f2\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3092\u7528\u3044\u305fAPOE4\u306b\u3088\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u89e3\u660e\u3000\u7b2c4\u56deAPOE\u7814\u7a76\u4f1a\u3000\u611b\u77e5\u30002025\u5e746\u670814\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    4. Yosuke Hashimoto, Gerg\u0151 Porkol\u00e1b, Natalie Hudson, Jeffrey O’Callaghan, Nicole Hanley, Chris\u3000Identification of novel negative regulators of claudin-5 in vascular endothelial cells by genome-wide\u3000Cerebral Vascular Biology\u3000Michigan\u3000June 29-July 2,2025, Poster<\/li>\n\n
    5. \u6a4b\u672c \u6d0b\u4f51\u3001Chris Greene\u3001Nicole Hanley\u3001Natalie Hudson\u3001David Henshall\u3001Kieron J. Sweeney \u3001Donncha F. O’Brien\u3001Matthew Campbell\u3000Claudin-5\u306e\u767a\u73fe\u91cf\u3092\u4f4e\u6e1b\u3055\u305b\u308b\u4e00\u5869\u57fa\u591a\u578b\u306fRNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8ceapumilio-a\u3078\u306e\u7d50\u5408\u6027\u3092\u5909\u3048\u308b\u3000\u65e5\u672c\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u5b66\u4f1a2025\u5e74\u5927\u4f1a\u3000\u5343\u8449\u30002025\u5e748\u67086\u65e5\u3000\u53e3\u982d\u767a\u8868\u3001Poster<\/li>\n\n
    6. Yasuo Uchida\u3000Spatial proteomics using AI-assisted laser microdissection to comprehensively quantify the absolute abundance of ECM proteins in region of interest in tissues\u3000Transformative Research Area (A) Integration of Extracellular Information by Multimodal ECM Activity 4th Group Meeting\u3000\u5fa1\u6bbf\u5834\u30002025\u5e749\u67081\u65e5\u3000\u30dd\u30b9\u30bf\u30fc<\/li>\n\n
    7. Yasuo Uchida\u3000Spatial proteomics using AI-assisted laser microdissection to comprehensively quantify the absolute abundance of ECM proteins in region of interest in tissues\u3000Transformative Research Area (A) Integration of Extracellular Information by Multimodal ECM Activity 4th Group Meeting\u3000\u5fa1\u6bbf\u5834\u30002025\u5e749\u67082\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    8. Yasuo Uchida\u3000Spatial proteomics using AI-assisted laser microdissection to comprehensively quantify the absolute abundance of ECM proteins in region of interest in tissues\u3000International Symposium on Multimodal ECM\u3000\u5fa1\u6bbf\u5834\u30002025\u5e749\u67083\u65e5\u3000\u30dd\u30b9\u30bf\u30fc<\/li>\n\n
    9. \u9ad8\u7530 \u7be4\u6765\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u5ddd\u898b \u660c\u53f2\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580PEPT2\u306b\u3088\u308b\u03b2\u30e9\u30af\u30bf\u30e0\u7cfb\u6297\u83cc\u85ac\u306e\u8133\u810a\u9ac4\u6db2\u304b\u3089\u306e\u6392\u51fa\u8f38\u9001\u6a5f\u80fd\u89e3\u660e\u3000\u7b2c1\u56de\u971e\u9053\u5834\u3000\u5e83\u5cf6\u30002025\u5e749\u670830\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    10. \u5ca1\u6751 \u7fd4\u592a\u3001\u524d\u7530 \u7950\u5e0c\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u6e05\u6c34 \u5b8f\u3001\u4e2d\u68ee \u96c5\u4e4b\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u9ad8\u6df1\u5ea6\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u89e3\u6790\u3092\u7528\u3044\u305f\u7b4b\u5f37\u76f4\u6027\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc1\u578b\u60a3\u8005\u306e\u5074\u982d\u8449\u767d\u8cea\u306b\u304a\u3051\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u95a2\u9023\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u7b2c1\u56de\u971e\u9053\u5834\u3000\u5e83\u5cf6\u30002025\u5e749\u670830\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    11. \u6ce2\u5185 \u5b8f\u6597\u3001\u6a4b\u672c\u6d0b\u4f51\u3001Claude Besmond\u3001Nathalie Boddaert\u3001\u5185\u7530\u5eb7\u96c4\u3001Arnold Munnich\u3001Matthew Campbell\u3000\u5148\u5929\u6027\u5927\u8133\u767d\u8cea\u5f62\u6210\u4e0d\u5168\u75c7\u306e\u60a3\u8005\u3067\u767a\u898b\u3055\u308c\u305fCLDND1\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u4f53\u306e\u6a5f\u80fd\u89e3\u6790\u3000\u7b2c1\u56de\u971e\u9053\u5834\u3000\u5e83\u5cf6\u30002025\u5e749\u670830\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    12. \u5c71\u53e3 \u660e\u65e5\u7fd4\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u5ddd\u898b \u660c\u53f2\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580\u306b\u9ad8\u767a\u73fe\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306ein vivo\u6392\u51fa\u8f38\u9001\u6a5f\u80fd\u306e\u89e3\u660e\u3000\u7b2c1\u56de\u971e\u9053\u5834\u3000\u5e83\u5cf6\u30002025\u5e749\u670830\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
    13. Yosuke Hashimoto, Xiuyuan Zhan, Yasuo Uchida, Adam McGlinchey, Matthew Campbell, Angela Garcia-Gallardo, and Donncha O\u2019Brien\u3000SWATH-MS Proteomic Profiling of Blood-Brain Barrier Dynamics in Glioblastoma: Longitudinal Plasma and Spatial Tumor Tissue Analysis\u3000\u7b2c1\u56de\u971e\u9053\u5834\u3000\u5e83\u5cf6\u30002025\u5e749\u670830\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
    14. \u5c71\u53e3 \u660e\u65e5\u7fd4\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u5ddd\u898b \u660c\u53f2\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580\u306b\u9ad8\u767a\u73fe\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306ein vivo\u6392\u51fa\u8f38\u9001\u6a5f\u80fd\u306e\u8a3c\u660e\u3000\u7b2c4\u56de\u5e83\u5cf6\u5927\u5b66\u8133\u795e\u7d4c\u79d1\u5b66\u30bb\u30df\u30ca\u30fc\u3000\u5e83\u5cf6\u30002025\u5e7410\u67089\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
    15. \u524d\u7530 \u7950\u5e0c, \u6a4b\u672c \u6d0b\u4f51, \u7af9\u6797 \u4f73\u5b50, \u77f3\u5ddd \u82e5\u82b8, \u5c71\u5d0e \u96c4, \u6e05\u6c34 \u5b8f, \u5c0f\u91ce \u9ebb\u8863\u5b50, \u9ad8\u5802 \u88d5\u5e73, \u4e38\u5c71 \u535a\u6587, \u5ddd\u898b \u660c\u53f2, \u5185\u7530 \u5eb7\u96c4\u3000APOE4\u306b\u3088\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u306b\u5411\u3051\u305f\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u89e3\u6790\u3000\u7b2c4\u56de\u5e83\u5cf6\u5927\u5b66\u8133\u795e\u7d4c\u79d1\u5b66\u30bb\u30df\u30ca\u30fc\u3000\u5e83\u5cf6\u30002025\u5e7410\u67089\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
    16. \u6a4b\u672c \u6d0b\u4f51, Gergo Porkolab, Natalie Hudson,Zhan Xiuyuan , Karine Poirier, Nathalie Boddaert,\u5185\u7530 \u5eb7\u96c4, Arnold\u3000Munnich, Matthew Campbell\u3000\u5c0f\u5150\u4ea4\u4e92\u6027\u7247\u9ebb\u75fa\u3092\u8a98\u767a\u3059\u308bCLDN5\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u4f53\u306e\u767a\u898b\u3068\u305d\u306e\u6a5f\u80fd\u89e3\u6790\u3000\u7b2c68\u56de\u65e5\u672c\u8133\u5faa\u74b0\u4ee3\u8b1d\u5b66\u4f1a\u3000\u3055\u3044\u305f\u307e\u30002025\u5e7410\u670817\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    17. Asuka Yamaguchi, Yosuke Hashimoto, Masashi Kawami, Yasuo Uchida\u3000In vivo contribution of drug efflux across the blood-arachnoid barrier from CSF: Roles of organic cation and multidrug efflux transporters\u3000\u65e5\u672c\u85ac\u7269\u52d5\u614b\u5b66\u4f1a\u7b2c40\u56de\u5e74\u4f1a\u3000\u4eac\u90fd 2025\u5e7410\u670823\u65e5 \u53e3\u982d\u767a\u8868\uff08\u82f1\u8a9e\uff09<\/li>\n\n
    18. Taichi Ono, Akari Uda, Yosuke Hashimoto, Yasuo Uchida\u3000Comprehensive determination of apical and basolateral localization for choroid plexus membrane proteins\u3000\u65e5\u672c\u85ac\u7269\u52d5\u614b\u5b66\u4f1a\u7b2c40\u56de\u5e74\u4f1a\u3000\u4eac\u90fd 2025\u5e7410\u670823\u65e5 \u53e3\u982d\u767a\u8868\uff08\u82f1\u8a9e\uff09<\/li>\n\n
    19. Atsuki Takata, Yosuke Hashimoto, Masashi Kawami, Yasuo Uchida\u3000Elucidation of the in vivo efflux transport by peptide transporter PEPT2 at the blood-arachnoid-barrier in the elimination of \u03b2-lactam antibiotics from CSF\u3000\u65e5\u672c\u85ac\u7269\u52d5\u614b\u5b66\u4f1a\u7b2c40\u56de\u5e74\u4f1a\u3000\u4eac\u90fd 2025\u5e7410\u670823\u65e5 \u53e3\u982d\u767a\u8868\uff08\u82f1\u8a9e\uff09<\/li>\n\n
    20. Yuki Maeda, Yosuke Hashimoto, Yoshiko Takebayashi, Ishikawa Ruoyi, Yu Yamazaki, Hiroshi Shimizu, Maiko Ono, Yuhei Takado, Hirofumi Maruyama, Yasuo Uchida\u3000Unraveling APOE4-Driven Pathogenic Mechanisms of Alzheimer\u2019s Disease through Highly Deep Quantitative Proteomics\u3000The first knowledge exchange between Korean MPS engineers and Japanese barriologists  \u5e83\u5cf6 Oct 23-25, 2025 \u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
    21. Atsuki Takata, Yosuke Hashimoto, Masashi Kawami, Yasuo Uchida\u3000Elucidation of the in vivo efflux transport by peptide transporter PEPT2 at the blood-arachnoid-barrier in the elimination of \u03b2-lactam antibiotics from CSF\u3000The first knowledge exchange between Korean MPS engineers and Japanese barriologists  \u5e83\u5cf6 Oct 23-25, 2025 \u53e3\u982d\u767a\u8868\uff08\u82f1\u8a9e\uff09<\/li>\n\n
    22. Haruaki Ishikawa, Yosuke Hashimoto, Chris Greene, Nicole Hanley, Natalie Hudson, David Henshall, Kieron J. Sweeney, Donncha F. O’Brien, Yasuo Uchida, Matthew Campbell\u3000A single nucleotide polymorphism in CLDN5 gene attenuates the binding ability to Pumilio RNA-binding protein \u3000The first knowledge exchange between Korean MPS engineers and Japanese barriologists  \u5e83\u5cf6 Oct 23-25, 2025 \u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
    23. Haruka Ono, Yosuke Hashimoto, Gerg\u0151 Porkol\u00e1b, Natalie Hudson, Jeffrey O’Callaghan, Nicole Hanley, Chris Greene, Yasuo Uchida, M\u00e1ria A. Deli, Matthew Campbell Identification of novel negative regulators of claudin-5 in vascular endothelial cells by genome-wide screening The first knowledge exchange between Korean MPS engineers and Japanese barriologists  \u5e83\u5cf6 Oct 23-25, 2025 \u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
    24. \u5c0f\u91ce \u592a\u7a1a\u3001\u5b87\u7530\u6731\u91cc\u3001\u6a4b\u672c\u6d0b\u4f51\u3001\u5185\u7530 \u5eb7\u96c4 \u8108\u7d61\u53e2\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9802\u7aef\u819c\u5074\u304a\u3088\u3073\u57fa\u5e95\u819c\u5074\u5c40\u5728\u306e\u5305\u62ec\u7684\u6c7a\u5b9a \u7b2c46\u56de \u751f\u4f53\u819c\u3068\u85ac\u7269\u306e\u76f8\u4e92\u4f5c\u7528\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u6ecb\u8cc0 2025\u5e7411\u67086\u65e5 \u53e3\u982d\u767a\u8868<\/li>\n\n
    25. \u6a4b\u672c \u6d0b\u4f51, Gergo Porkolab, Natalie Hudson, Karine Poirier, Nathalie Boddaert, Arnold Munnich, \u5185\u7530 \u5eb7\u96c4, Matthew Campbell\u3000\u75be\u60a3\u8a98\u767a\u578bCLDN5\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u4f53\u306e\u767a\u898b\u3068\u305d\u306e\u6a5f\u80fd\u89e3\u6790\u3000\u7b2c64\u56de\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u30fb\u65e5\u672c\u85ac\u5264\u5e2b\u4f1a\u30fb\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u4e2d\u56fd\u56db\u56fd\u652f\u90e8\u5b66\u8853\u5927\u4f1a \u5fb3\u5cf6 2025\u5e7411\u67088\u65e5 \u53e3\u982d\u767a\u8868<\/li>\n\n
    26. \u5ca1\u6751 \u7fd4\u592a\u3001\u524d\u7530 \u7950\u5e0c\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u6e05\u6c34 \u5b8f\u3001\u4e2d\u68ee \u96c5\u4e4b\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u9ad8\u6df1\u5ea6\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u89e3\u6790\u306b\u3088\u308b\u7b4b\u5f37\u76f4\u6027\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc1\u578b\u60a3\u8005\u306e\u5074\u982d\u8449\u767d\u8cea\u306b\u304a\u3051\u308b\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u7b2c64\u56de\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u30fb\u65e5\u672c\u85ac\u5264\u5e2b\u4f1a\u30fb\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u4e2d\u56fd\u56db\u56fd\u652f\u90e8\u5b66\u8853\u5927\u4f1a \u5fb3\u5cf6 2025\u5e7411\u67088\u65e5 \u53e3\u982d\u767a\u8868<\/li>\n\n
    27. \u4e09\u4e95 \u54b2\u826f\u3001 \u6a4b\u672c \u6d0b\u4f51\u3001 \u6771 \u5948\u83dc\u3001 Chris Greene\u3001 Matthew Campbell\u3001 \u6e05\u6c34 \u82b3\u5b9f\u3001 \u6df1\u6fa4 \u5f81\u7fa9\u3001 \u5185\u7530 \u5eb7\u96c4\u3000Covid-19\u9577\u671f\u5f8c\u907a\u75c7brain fog\u4e0b\u3067\u751f\u3058\u308b\u8133\u8840\u7ba1\u969c\u5bb3\u306e\u672c\u8cea\u3092\u63a2\u308b\u3000\u7b2c64\u56de\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u30fb\u65e5\u672c\u85ac\u5264\u5e2b\u4f1a\u30fb\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u4e2d\u56fd\u56db\u56fd\u652f\u90e8\u5b66\u8853\u5927\u4f1a \u5fb3\u5cf6 2025\u5e7411\u67088\u65e5 \u53e3\u982d\u767a\u8868<\/li>\n\n
    28. \u6ce2\u5185 \u5b8f\u6597\u3001\u6a4b\u672c\u3000\u6d0b\u4f51\u3001Claude\u3000Besmond\u3001Nathalie\u3000Boddaert\u3001\u5185\u7530\u3000\u5eb7\u96c4\u3001Arnold\u3000Munnich\u3001Matthew\u3000Campbell\u3000\u5148\u5929\u6027\u5927\u8133\u767d\u8cea\u5f62\u6210\u4e0d\u5168\u75c7\u306e\u60a3\u8005\u3067\u767a\u898b\u3055\u308c\u305fCLDND1\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u4f53\u306e\u6a5f\u80fd\u89e3\u6790\u3000\u7b2c64\u56de\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u30fb\u65e5\u672c\u85ac\u5264\u5e2b\u4f1a\u30fb\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u4e2d\u56fd\u56db\u56fd\u652f\u90e8\u5b66\u8853\u5927\u4f1a \u5fb3\u5cf6 2025\u5e7411\u67088\u65e5 \u53e3\u982d\u767a\u8868<\/li>\n\n
    29. \u524d\u7530 \u7950\u5e0c, \u6a4b\u672c \u6d0b\u4f51, \u7af9\u6797 \u4f73\u5b50, \u77f3\u5ddd \u82e5\u82b8, \u5c71\u5d0e \u96c4, \u6e05\u6c34 \u5b8f, \u5c0f\u91ce \u9ebb\u8863\u5b50, \u9ad8\u5802 \u88d5\u5e73, \u4e38\u5c71 \u535a\u6587, \u5ddd\u898b \u660c\u53f2, \u5185\u7530 \u5eb7\u96c4\u3000\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3092\u7528\u3044\u305fAPOE4\u306b\u3088\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u89e3\u660e\u3000\u7b2c44\u56de\u65e5\u672c\u8a8d\u77e5\u75c7\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a \u65b0\u6f5f 2025\u5e7411\u670821\u65e5 \u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
    30. Yosuke Hashimoto, Gergo Porkolab, Natalie Hudson, Zhan Xiuyuan, Karine Poirier, Nathalie Boddaert, Yasuo Uchida, Arnold Munnich, Matthew Campbell\u3000Functional analysis of a pathogenic CLDN5 missense mutation associated with alternating hemiplegia\u3000\u65e5\u672c\u4eba\u985e\u907a\u4f1d\u5b66\u4f1a\u7b2c 70 \u56de\u5927\u4f1a \u6a2a\u6d5c 2025\u5e7412\u670818\u65e5-20\u65e5 \u53e3\u982d\u767a\u8868\uff08\u82f1\u8a9e\uff09<\/li>\n\n
    31. \u5185\u7530 \u5eb7\u96c4\u3000\u591a\u69d8\u306a\u751f\u7269\u306b\u9069\u7528\u3067\u304d\u308b\u7db2\u7f85\u7684\u304b\u3064\u9ad8\u7cbe\u5ea6\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u30fb\u30ea\u30f3\u9178\u5316\u7d76\u5bfe\u5b9a\u91cf\u6cd5\u306e\u958b\u767a\u3000\u5b66\u8853\u5909\u9769\u9818\u57df\u7814\u7a76\uff08A\uff09\u300c\u6642\u9593\u30bf\u30f3\u30d1\u30af\u8cea\u5b66\u300d2025\u5e74\u5ea6 \u9818\u57df\u4f1a\u8b70\u3000\u82a6\u539f\u6e29\u6cc9\u30002026\u5e741\u670810\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    32. \u6a4b\u672c\u6d0b\u4f51\u3000CLDN5\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u4f53\u304c\u8a98\u767a\u3059\u308b\u4e2d\u67a2\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u767a\u898b\u3000\u7b2c\u4e09\u56deNeuro\u971e\u3000\u5e83\u5cf6\u30002026\u5e742\u670817\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    33. \u5c0f\u91ce\u592a\u7a1a\u3001\u5b87\u7530\u6731\u91cc\u3001\u6a4b\u672c\u6d0b\u4f51\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u5bc6\u5ea6\u52fe\u914d\u9060\u5fc3\u3068 DIA \u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3092\u7528\u3044\u305f\u8108\u7d61\u53e2\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u5c40\u5728\u89e3\u6790\u3000\u7b2c\u4e09\u56deNeuro\u971e\u3000\u5e83\u5cf6\u30002026\u5e742\u670817\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    34. \u5c0f\u91ce\u592a\u7a1a\u3001\u5b87\u7530\u6731\u91cc\u3001\u6a4b\u672c\u6d0b\u4f51\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u6297\u4f53\u3092\u7528\u3044\u305a\u306b\u8108\u7d61\u53e2\u4e0a\u76ae\u7d30\u80de\u306e apical\/basolateral \u819c\u5c40\u5728\u3092\u7db2\u7f85\u7684\u306b\u6c7a\u5b9a\u3059\u308b\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c146\u5e74\u4f1a\u3000\u5927\u962a\u30002026\u5e743\u670827\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    35. \u6ce2\u5185 \u5b8f\u6597\u3000\u300c\u85ac\u5b66\u306b\u304a\u3051\u308b\u5730\u57df\u533b\u7642\u6559\u80b2\u306e\u8ab2\u984c\u3068\u305d\u306e\u89e3\u6c7a\u7b56\u3092\u8003\u3048\u308b\uff01\u300d\u6587\u90e8\u79d1\u5b66\u7701\u9ad8\u5ea6\u533b\u7642\u4eba\u6750\u990a\u6210\u62e0\u70b9\u5f62\u6210\u4e8b\u696d\u306e\u53c2\u753b\u3059\u308b\u85ac\u5b66\u751f\u30fb\u6559\u54e1\u304b\u3089\u306e\u63d0\u8a00\u3000\u5408\u540c\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d7\u3067\u8a71\u3057\u5408\u3063\u305f\u5185\u5bb9\u306e\u5b66\u751f\u4ee3\u8868\u767a\u8868\u300c\u85ac\u5b66\u90e8\u3078\u306e\u6559\u80b2\u63d0\u6848\u300d\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c146\u5e74\u4f1a\u3000\u5927\u962a\u30002026\u5e743\u670828\u65e5\u3000\u53e3\u982d\u767a\u8868\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff09\u3000<\/li>\n\n
    36. \u5ca1\u6751 \u7fd4\u592a\u3001\u524d\u7530 \u7950\u5e0c\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u6e05\u6c34 \u5b8f\u3001\u4e2d\u68ee \u96c5\u4e4b\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u9ad8\u6df1\u5ea6\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u89e3\u6790\u306b\u3088\u308b\u7b4b\u5f37\u76f4\u6027\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc1\u578b\u60a3\u8005\u306e\u5074\u982d\u8449\u767d\u8cea\u306b\u304a\u3051\u308b\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c146\u5e74\u4f1a\u3000\u5927\u962a\u30002026\u5e743\u670827\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
    37. Xiuyuan Zhan, Adam McGlinchey, Angela Garcia-Gallardo, Jeffrey O\u2019Callaghan, Yosuke Hashimoto, Yasuo Uchida, Kieron Sweeney, Donncha O\u2019Brien, Matthew Campbell\u3000Integrated proteomic analysis of resected tumor tissues and longitudinally collected plasma from patients with glioblastoma\u30008th Mini-Symposium on the Blood\u2013Brain Barrier\u3000Szeged, Hungary\u3000March 26-28,2026 Poster<\/li><\/ol>

      2024\u5e74\u5ea6<\/h2>

      \u62db\u5f85<\/h2>
      1. \u5185\u7530 \u5eb7\u96c4\u3000\u30d1\u30e9\u30d5\u30a3\u30f3\u5207\u7247\u3092\u7528\u3044\u305f\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\uff1a \u3069\u306e\u3088\u3046\u306b\u52b9\u7387\u7684\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u62bd\u51fa\u3092\u5b9f\u73fe\u3059\u308b\u304b\u3000\u65e5\u672c\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u5b66\u4f1a2024\u5e74\u5927\u4f1a\u30fb \u7b2c20\u56de\u65e5\u672c\u81e8\u5e8a\u30d7\u30ed\u30c6\u30aa\u30b2\u30ce\u30df\u30af\u30b9\u5b66\u4f1a \u5408\u540c\u5927\u4f1a\u3000\u9752\u68ee\u30002024\u5e7406\u670826\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
      2. \u5185\u7530 \u5eb7\u96c4\u3000\u8133\u795e\u7d4c\u75be\u60a3\u6cbb\u7642\u3092\u6a19\u7684\u3068\u3059\u308b\u4e2d\u67a2\u95a2\u9580\u3068\u8133\u5185\u75c5\u614b\u306e\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u7814\u7a76\u3000\u65e5\u672c\u85ac\u5264\u5b66\u4f1a\u7b2c39\u5e74\u4f1a\u3000\u795e\u6238\u30002024\u5e7405\u670823\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li><\/ol>

        \u4e00\u822c<\/h2>
        1. \u897f\u6751 \u67da\u5948\u3001\u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u897f\u5c3e \u4e00\u771f\u3001\u7530\u91ce \u5149\u654f\u3001\u9ad8\u5c3e \u660c\u6a39\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u30d2\u30c8\u306e\u30d1\u30e9\u30d5\u30a3\u30f3\u7d44\u7e54\u306e\u5206\u5b50\u6a5f\u69cb\u89e3\u660e\u306b\u304a\u3051\u308b\u75c5\u7406\u6a19\u672c\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9FFPE-PCT-SWATH\u6cd5\u306e\u6709\u7528\u6027\u306e\u5b9f\u8a3c\u3000\u65e5\u672c\u85ac\u5264\u5b66\u4f1a\u7b2c39\u5e74\u4f1a\u3000\u795e\u6238\u30002024\u5e7405\u670823\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
        2. \u8d64\u4e95 \u7f8e\u6708\u3001\u5ddd\u898b \u660c\u53f2\u3001\u5185\u7530 \u5eb7\u96c4\u3000MicroRNA\u5275\u85ac\u3092\u6307\u5411\u3057\u305f\u65b0\u898fmicroRNA-\u30bf\u30f3\u30d1\u30af\u8cea\u30da\u30a2\u30ea\u30f3\u30b0\u89e3\u6790\u6cd5\u306e\u69cb\u7bc9\u3000\u65e5\u672c\u85ac\u5264\u5b66\u4f1a\u7b2c39\u5e74\u4f1a\u3000\u795e\u6238\u30002024\u5e7405\u670823\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
        3. \u718a\u8c37 \u96c4\u592a\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u9032\u884c\u6027\u6838\u4e0a\u6027\u9ebb\u75fa\u60a3\u8005\u306e\u8133\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7db2\u7f85\u7684\u5b9a\u91cf\u306b\u3088\u308b\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u65e5\u672c\u85ac\u5264\u5b66\u4f1a\u7b2c39\u5e74\u4f1a\u3000\u795e\u62382024\u5e7405\u670823\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
        4. \u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u30d7\u30ed\u30c6\u30aa\uff08\u30ce\u30a6\uff09\u30df\u30af\u30b9\u304c\u89e3\u304d\u660e\u304b\u3059\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u771f\u5b9f\u3000\u65e5\u672c\u85ac\u5264\u5b66\u4f1a\u7b2c39\u5e74\u4f1a\u3000\u795e\u6238\u30002024\u5e7405\u670823\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
        5. Yasuo Uchida, Next generation quantitative proteomics-based central nervous system barrier studies, 2024 ISSX\/JSSX Meeting, HAWAI, Sep 15-18, 2024, Poster<\/li>\n\n
        6. Yuta Kumagai, Masashi Kawami, Yurika Abe, Hiroshi Shimizu, Jun Nagai, Maiko Ono, Yuhei Takdo, and Yasuo Uchida, Quantitative proteomics-based identification of novel therapeutic targets for progressive supranuclear palsy using post-mortem human brain, 2024 ISSX\/JSSX Meeting, HAWAI, Sep 15-18, 2024, Poster<\/li>\n\n
        7. Yuki Maeda, Masashi Kawami, Yurika Abe, Hiroshi Shimizu, Jun Nagai, Maiko Ono, Yuhei Takdo, and Yasuo Uchida, Highly deep quantitative proteomics elucidate the mechanism of alzheimers’ disease targeting reactive strocyte, 2024 ISSX\/JSSX Meeting, HAWAI, Sep 15-18, 2024, Poster<\/li>\n\n
        8. Masashi Kawami, Airi Fukushima, Ryoko Yumoto, Mikihisa Takano, and Yasuo Uchida, Bridging targeted metabolomics to global proteomics approach to clarify ribavirin-induced resistance in breast cancer MCF-7 cells, 2024 ISSX\/JSSX Meeting, HAWAI, Sep 15-18, 2024, Poster<\/li>\n\n
        9. \u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u7950\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u5e2f\u72b6\u56de\u9818\u57df\u306b\u304a\u3051\u308b\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u89e3\u6790~\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u6d3b\u6027\u5316\u6a5f\u69cb\u306e\u540c\u5b9a\uff5e\u3001\u7b2c\uff13\u56de\u5e83\u5cf6\u5927\u5b66\u8133\u795e\u7d4c\u79d1\u5b66\u30bb\u30df\u30ca\u30fc\u3001\u5e83\u5cf6\u5927\u5b66\u5e83\u4ec1\u4f1a\u9928\uff08\u971e\u30ad\u30e3\u30f3\u30d1\u30b9\uff09\u30012024\u5e7410\u67087\u65e5\u3001Poster<\/li>\n\n
        10. \u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u7af9\u6797 \u4f73\u5b50\u3001\u77f3\u5ddd \u82e5\u82b8\u3001\u5c71\u5d0e \u96c4\u3001\u6e05\u6c34 \u5b8f\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u4e38\u5c71 \u535a\u6587\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u5185\u7530 \u5eb7\u96c4\u3001\u7db2\u7f85\u7684\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u89e3\u6790\u3092\u7528\u3044\u305f\u30a2\u30dd\u30ea\u30dd\u86cb\u767dE4\u306b\u3088\u308b\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u84c4\u7a4d\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3001\u7b2c63\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u30fb\u65e5\u672c\u85ac\u5264\u5e2b\u4f1a\u30fb\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u4e2d\u56fd\u56db\u56fd\u652f\u90e8\u5b66\u8853\u5927\u4f1a\u3001\u5ca1\u5c71\u30012024\u5e7411\u670817\u65e5\u3001\u53e3\u982d\u767a\u8868<\/li>\n\n
        11. Yosuke Hashimoto, Natalie Hudson, Nathalie Boddaert, Arnold Munnich, Matthew Campbell, Not only ATP1A3 mutations: a novel de novo CLDN5 missense mutation found in two independent, 12th Symposium on ATP1A3 in Disease, Barcelona, Spain, Nov 14-15, 2024, Poster<\/li>\n\n
        12. \u5c71\u53e3 \u660e\u65e5\u7fd4\u3001\u5ddd\u898b \u660c\u53f2\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u5185\u7530 \u5eb7\u96c4\u3001\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580\u306e\u30ab\u30c1\u30aa\u30f3\u6027\u30fb\u8102\u6eb6\u6027\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306ein vivo\u6392\u51fa\u8f38\u9001\u6a5f\u80fd\u306e\u8a3c\u660e\u3001\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c145\u5e74\u4f1a\u3001\u798f\u5ca1\u30012025\u5e743\u670827\u65e5\u3001\u53e3\u982d\u767a\u8868<\/li>\n\n
        13. \u9577\u5ca1 \u4f51\u6a39\u3001\u4f50\u85e4 \u7406\u6c99\u3001\u4f50\u85e4 \u54f2\u3001\u8d64\u5ddd \u30e9\u30ea\u30d6\u30ec\u30c0\u3001\u5ddd\u898b \u660c\u53f2\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u5185\u7530 \u5eb7\u96c4\u3001\u8840\u6db2\u8133\u95a2\u9580\u306b\u9ad8\u767a\u73fe\u3059\u308bMFSD10\u306e\u795e\u7d4c\u8208\u596e\u306e\u5236\u5fa1\u3078\u306e\u5bc4\u4e0e\u306e\u89e3\u660e\u3001\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c145\u5e74\u4f1a\u3001\u798f\u5ca1\u30012025\u5e743\u670827\u65e5\u3001\u53e3\u982d\u767a\u8868<\/li>\n\n
        14. \u9ad8\u7530 \u7be4\u6765\u3001\u5ddd\u898b \u660c\u53f2\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u5185\u7530 \u5eb7\u96c4\u3001\u03b2\u30e9\u30af\u30bf\u30e0\u7cfb\u6297\u83cc\u85ac\u306e\u8133\u810a\u9ac4\u6db2\u304b\u3089\u306e\u6392\u51fa\u306b\u304a\u3051\u308b\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580\u30da\u30d7\u30c1\u30c9\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fcPEPT2\u306e\u95a2\u4e0e\u3001\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c145\u5e74\u4f1a\u3001\u798f\u5ca1\u30012025\u5e743\u670827\u65e5\u3001\u53e3\u982d\u767a\u8868<\/li>\n\n
        15. \u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u7af9\u6797 \u4f73\u5b50\u3001\u77f3\u5ddd \u82e5\u82b8\u3001\u5c71\u5d0e \u96c4\u3001\u6e05\u6c34 \u5b8f\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u4e38\u5c71 \u535a\u6587\u3001\u6a4b\u672c \u6d0b\u4f51\u3001\u5185\u7530 \u5eb7\u96c4\u3001\u9ad8\u6df1\u5ea6\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u89e3\u6790\u306b\u57fa\u3065\u304f\u30a2\u30dd\u30ea\u30dd\u86cb\u767dE4\u306b\u3088\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3001\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c145\u5e74\u4f1a\u3001\u798f\u5ca1\u30012025\u5e743\u670827\u65e5\u3001\u53e3\u982d\u767a\u8868<\/li><\/ol>

          2023\u5e74\u5ea6<\/h2>

          \u62db\u5f85<\/h2>
          1. \u5185\u7530 \u5eb7\u96c4\u3000\u65e5\u672c\u304c\u8a87\u308b\u30d6\u30ec\u30a4\u30f3\u30d0\u30f3\u30af\u306e\u30d2\u30c8\u8133\u7d44\u7e54\u3092\u6d3b\u7528\u3057\u305f\u75c5\u614b\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u7814\u7a76\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u5e74\u4f1a\u3000\u6a2a\u6d5c\u30002024\u5e7403\u670828\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
          2. \u5185\u7530 \u5eb7\u96c4\u3000Next Generation Quantitative Proteomics\u306b\u3088\u3063\u3066\u62d3\u304b\u308c\u308b\u4e2d\u67a2\u95a2\u9580\u7814\u7a76\u306e\u65b0\u5c55\u958b\u3000\u7b2c\uff11\uff14\uff19\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u4e2d\u56fd\u56db\u56fd\u652f\u90e8\u4f8b\u4f1a\u3000\u5e83\u5cf6\u30002024\u5e7401\u670827\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
          3. \u5185\u7530 \u5eb7\u96c4\u3000\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u306b\u57fa\u3065\u304f\u85ac\u7269\u8f38\u9001\u7814\u7a76\u3000\u5275\u85ac\u52d5\u614b\u30d5\u30a9\u30fc\u30e9\u30e0in\u91d1\u6ca2\u3000\u91d1\u6ca2\u5927\u5b66\u30002024\u5e7401\u670815\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
          4. \u5185\u7530 \u5eb7\u96c4\u3000\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u306b\u3088\u308b\u4e2d\u67a2\u7d44\u7e54\u306e\u8f38\u9001\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u65e5\u672c\u819c\u5b66\u4f1a\u300c\u7b2c45\u5e74\u4f1a\u300d\u30fb\u300c\u819c\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02023\u300d\u5408\u540c\u5927\u4f1a\u3000\u6771\u4eac\u30002023\u5e7411\u670820\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
          5. Yasuo Uchida\u3000Next generation quantitative proteomics opens up the new fields of central nervous system barrier studies\u3000Korean Society of Applied Pharmacology (KSAP) annual meeting 2023\u3000Korea\u30002023\u5e7410\u670806\u65e5\u3000Oral<\/li>\n\n
          6. \u5185\u7530 \u5eb7\u96c4\u3000\u6700\u65b0\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u7814\u7a76\u306b\u3088\u3063\u3066\u62d3\u304b\u308c\u308b\u6b21\u4e16\u4ee3\u306e\u4e2d\u67a2\u75be\u60a3\u6cbb\u7642\u3000\u4ee4\u548c5\u5e74\u5ea6\u30d2\u30ed\u30b7\u30de\u85ac\u5264\u5e2b\u7814\u4fee\u4f1a\u3000\u5e83\u5cf6\u30002023\u5e7407\u670830\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
          7. \u5185\u7530 \u5eb7\u96c4\u3000\u30d2\u30c8\u81e8\u5e8a\u691c\u4f53\u3092\u7528\u3044\u305f\u4e2d\u67a2\u95a2\u9580\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3000\u65e5\u672c\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u5b66\u4f1a2023\u5e74\u5927\u4f1a\u3000\u65b0\u6f5f\u30002023\u5e7407\u670824\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
          8. \u5185\u7530 \u5eb7\u96c4\u3000\u6b21\u4e16\u4ee3\u578b\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3092\u7528\u3044\u305f\u91d1\u5c5e\u30c8\u30e9\u30d5\u30a3\u30c3\u30af\u7814\u7a76\u3000\u7b2c23\u56de \u65e5\u672c\u86cb\u767d\u8cea\u79d1\u5b66\u4f1a\u5e74\u4f1a\u3000\u540d\u53e4\u5c4b\u30002023\u5e7407\u670805\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
          9. Yasuo Uchida\u3000Next generation quantitative proteomics opens up the new fields of CNS barrier studies\u3000CVB2023 conference\u3000Uppsala, Sweden\u30002023\u5e7406\u670818\u65e5\u3000Oral<\/li>\n\n
          10. \u5185\u7530 \u5eb7\u96c4\u3000\u30d2\u30c8\u6b7b\u5f8c\u8133\u3092\u7528\u3044\u305f\u4e2d\u67a2\u95a2\u9580\u306b\u304a\u3051\u308b\u85ac\u7269\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u7814\u7a76\u3000\u7b2c64\u56de \u65e5\u672c\u795e\u7d4c\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u3000\u6771\u4eac\u30002023\u5e7405\u670831\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
          11. \u5185\u7530 \u5eb7\u96c4\u3000\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3092\u53d6\u308a\u5dfb\u304f\u795e\u7d4c\u8840\u7ba1\u30e6\u30cb\u30c3\u30c8\u3092\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3067\u6e2c\u5b9a\u3059\u308b\u3000\u7b2c34\u56de \u81e8\u5e8aMR\u8133\u6a5f\u80fd\u7814\u7a76\u4f1a\u3000\u6771\u4eac\u30002023\u5e7405\u670813\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
          12. \u5185\u7530 \u5eb7\u96c4\u3000\u30d2\u30c8\u6b7b\u5f8c\u8133\u3092\u6709\u52b9\u5229\u7528\u3059\u308b\u305f\u3081\u306e\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u7814\u7a76\u3000\u7b2c112\u56de\u65e5\u672c\u75c5\u7406\u5b66\u4f1a\u7dcf\u4f1a\u3000\u4e0b\u95a2\u30002023\u5e7404\u670813\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li><\/ol>

            \u4e00\u822c<\/h2>
            1. \u6749\u5143 \u52c7\u6bc5\u3001\u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9APPNL-G-F\u306e\u6d77\u99ac\u304a\u3088\u3073\u5927\u8133\u76ae\u8cea\u306e\u30d7\u30ed\u30c6\u30aa\u30bf\u30a4\u30d4\u30f3\u30b0\u306b\u3088\u308b\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u6d3b\u6027\u5316\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u5e74\u4f1a\u3000\u6a2a\u6d5c\u30002024\u5e7403\u670829\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            2. \u8d64\u4e95 \u7f8e\u6708\u3001\u5ddd\u898b \u660c\u53f2\u3001\u6e6f\u5143 \u826f\u5b50\u3001\u9ad8\u91ce \u5e79\u4e45\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u591a\u968e\u5c64\u30aa\u30df\u30af\u30b9\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u85ac\u7269\u306b\u3088\u308b\u80ba\u6bd2\u6027\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u5e74\u4f1a\u3000\u6a2a\u6d5c\u30002024\u5e7403\u670829\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            3. \u897f\u6751 \u67da\u5948\u3001\u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u897f\u5c3e \u4e00\u771f\u3001\u7530\u91ce \u5149\u654f\u3001\u9ad8\u5c3e \u660c\u6a39\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u75c5\u7406\u6a19\u672c\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u306b\u57fa\u3065\u304f\u30b7\u30cc\u30af\u30ec\u30a4\u30ce\u30d1\u30c1\u30fc\u60a3\u8005\u306e\u524d\u90e8\u5e2f\u72b6\u56de\u306b\u304a\u3051\u308b\u7db2\u7f85\u7684\u306a\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u5e74\u4f1a\u3000\u6a2a\u6d5c\u30002024\u5e7403\u670829\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            4. \u718a\u2f95 \u96c4\u592a\u3001\u5ddd\u2f92 \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u2fa5\u2fb9\u3001\u6e05\u2f54 \u5b8f\u3001\u2ed1\u4e95 \u6df3\u3001\u2f29\u91ce \u2fc7\u2f90\u2f26\u3001\u2fbc\u5802 \u88d5\u5e73\u3001\u5185\u2f65 \u5eb7\u96c4\u3000\u9032\u2f8f\u6027\u6838\u4e0a\u6027\u2fc7\u75fa\u60a3\u8005\u306e\u6b21\u4e16\u4ee3\u578b\u7db2\u7f85\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u89e3\u6790\u306b\u3088\u308b\u75c5\u614b\u5206\u2f26\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u5e74\u4f1a\u3000\u6a2a\u6d5c\u30002024\u5e7403\u670829\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            5. \u85e4\u4e95 \u5eb7\u4ecb, \u7af9\u5185 \u88d5\u5b5d, \u5ddd\u898b \u660c\u53f2, \u6e6f\u5143 \u826f\u5b50, \u9ad8\u91ce \u5e79\u4e45, \u5185\u7530 \u5eb7\u96c4\u3000\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u304a\u3051\u308b\u7d30\u83cc\u7531\u6765\u30da\u30d7\u30c1\u30c9\u306b\u3088\u308b\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3000\u6a2a\u6d5c\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u5e74\u4f1a\u30002024\u5e7403\u670829\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            6. \u5ddd\u898b \u660c\u53f2\u3001\u85e4\u672c \u5b87\u5b99\u3001\u5e73\u826f \u601c\u96c5\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u79cb\u7530 \u82f1\u4e07\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u30d7\u30ed\u30c6\u30aa\u30bf\u30a4\u30d4\u30f3\u30b0\u306b\u57fa\u3065\u304f\u30d2\u30c8\u8840\u7ba1\u5185\u76ae\u306e\u81d3\u5668\u7279\u7570\u7684\u6027\u8cea\u306e\u89e3\u660e\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u5e74\u4f1a\u3000\u6a2a\u6d5c\u30002024\u5e7403\u670829\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            7. \u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u9ad8\u6df1\u5ea6\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u306b\u57fa\u3065\u304f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u5f8c\u90e8\u5e2f\u72b6\u56de\u306b\u304a\u3051\u308b\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\uff1a\u904b\u52d5\u91ce\u76ae\u8cea\u3068\u306e\u6bd4\u8f03\u3000\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u5e74\u4f1a\u3000\u6a2a\u6d5c\u30002024\u5e7403\u670829\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            8. \u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u9ad8\u6df1\u5ea6\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u306b\u57fa\u3065\u304f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u5f8c\u90e8\u5e2f\u72b6\u56de\u306b\u304a\u3051\u308b\u75c5\u614b\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\uff1a\u904b\u52d5\u91ce\u76ae\u8cea\u3068\u306e\u5bfe\u7167\u5206\u6790\u3000\u7b2c\uff11\u56deNeuro\u971e\u82e5\u624b\u306e\u4f1a\u3000\u5e83\u5cf6\u30002024\u5e7402\u670814\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            9. \u718a\u2f95 \u96c4\u592a\u3001\u5ddd\u2f92 \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u2fa5\u2fb9\u3001\u6e05\u2f54 \u5b8f\u3001\u2ed1\u4e95 \u6df3\u3001\u2f29\u91ce \u2fc7\u2f90\u2f26\u3001\u2fbc\u5802 \u88d5\u5e73\u3001\u5185\u2f65 \u5eb7\u96c4\u3000\u9032\u884c\u6027\u6838\u4e0a\u6027\u9ebb\u75fa\u60a3\u8005\u306e\u8133\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u7b2c\uff11\u56deNeuro\u971e\u82e5\u624b\u306e\u4f1a\u3000\u5e83\u5cf6\u30002024\u5e7402\u670814\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            10. \u897f\u6751 \u67da\u5948\u3001\u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u897f\u5c3e \u4e00\u771f\u3001\u7530\u91ce \u5149\u654f\u3001\u9ad8\u5c3e \u660c\u6a39\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u30b7\u30cc\u30af\u30ec\u30a4\u30ce\u30d1\u30c1\u30fc\u60a3\u8005\u306e\u524d\u90e8\u5e2f\u72b6\u56de\u306b\u304a\u3051\u308b\u7db2\u7f85\u7684\u306a\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u7b2c\uff11\u56deNeuro\u971e\u82e5\u624b\u306e\u4f1a\u3000\u5e83\u5cf6\u30002024\u5e7402\u670814\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            11. \u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3000SWATH-MS\u6cd5\u3092\u7528\u3044\u305f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u5f8c\u90e8\u5e2f\u72b6\u56de\u306b\u304a\u3051\u308b\u7db2\u7f85\u7684\u306a\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u7b2c62\u56de \u65e5\u672c\u85ac\u5b66\u4f1a\u30fb\u65e5\u672c\u85ac\u5264\u5e2b\u4f1a\u30fb\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u4e2d\u56fd\u56db\u56fd\u652f\u90e8\u5b66\u8853\u5927\u4f1a\u3000\u9ad8\u77e5\u30002023\u5e7410\u670828\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            12. \u6749\u5143 \u52c7\u6bc5\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9APPNL-G-F\u306e\u6d77\u99ac\u304a\u3088\u3073\u5927\u8133\u76ae\u8cea\u306e\u30d7\u30ed\u30c6\u30aa\u30bf\u30a4\u30d4\u30f3\u30b0\u3000\u7b2c62\u56de \u65e5\u672c\u85ac\u5b66\u4f1a\u30fb\u65e5\u672c\u85ac\u5264\u5e2b\u4f1a\u30fb\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u4e2d\u56fd\u56db\u56fd\u652f\u90e8\u5b66\u8853\u5927\u4f1a\u3000\u9ad8\u77e5\u30002023\u5e7410\u670828\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            13. \u718a\u8c37 \u96c4\u592a\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3000SWATH-MS\u6cd5\u3092\u7528\u3044\u305f\u9032\u884c\u6027\u6838\u4e0a\u6027\u9ebb\u75fa\u60a3\u8005\u306e\u904b\u52d5\u91ce\u76ae\u8cea\u306b\u304a\u3051\u308b\u7db2\u7f85\u7684\u306a\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u7b2c62\u56de \u65e5\u672c\u85ac\u5b66\u4f1a\u30fb\u65e5\u672c\u85ac\u5264\u5e2b\u4f1a\u30fb\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u4e2d\u56fd\u56db\u56fd\u652f\u90e8\u5b66\u8853\u5927\u4f1a\u3000\u9ad8\u77e5\u30002023\u5e7410\u670828\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            14. \u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u9ad8\u6df1\u5ea6\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u306b\u3088\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u5f8c\u90e8\u5e2f\u72b6\u56de\u306b\u304a\u3051\u308b\u75c5\u614b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3000\u7b2c44\u56de \u751f\u4f53\u819c\u3068\u85ac\u7269\u306e\u76f8\u4e92\u4f5c\u7528\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u798f\u5ca1\u30002023\u5e7410\u670819\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            15. \u677e\u5ca1 \u7f8e\u7a7a\u3001\u5ddd\u898b \u660c\u53f2\uff0c\u6e6f\u5143 \u826f\u5b50\uff0c\u9ad8\u91ce \u5e79\u4e45\uff0c\u5185\u7530 \u5eb7\u96c4\u3000\u80ba\u80de\u4e0a\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3\u306b\u3088\u308b\u30da\u30d7\u30c1\u30c9\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fcPEPT2\u6a5f\u80fd\u306e\u963b\u5bb3\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u7b2c\uff12\u56de\u5e83\u5cf6\u5927\u5b66\u8133\u795e\u7d4c\u79d1\u5b66\u30bb\u30df\u30ca\u30fc\u3000\u5e83\u5cf6 2023\u5e7410\u670810\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
            16. \u6ce2\u6765\u8c37 \u5e0c\u5b9f\u3001\u5ddd\u898b \u660c\u53f2, \u6e6f\u5143 \u826f\u5b50, \u9ad8\u91ce \u5e79\u4e45, \u5185\u7530 \u5eb7\u96c4\u3000\u57f9\u990a\u7d30\u80de\u7cfb\u306b\u304a\u3051\u308b\u7d30\u80de\u5185pH\u5909\u52d5\u306b\u7740\u76ee\u3057\u305f\u30cb\u30b3\u30c1\u30f3\u8f38\u9001\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u7b2c\uff12\u56de\u5e83\u5cf6\u5927\u5b66\u8133\u795e\u7d4c\u79d1\u5b66\u30bb\u30df\u30ca\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7410\u670810\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
            17. \u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\u3001\u963f\u90e8 \u53cb\u91cc\u9999\u3001\u6e05\u6c34 \u5b8f\u3001\u9577\u4e95 \u6df3\u3001\u5c0f\u91ce \u9ebb\u8863\u5b50\u3001\u9ad8\u5802 \u88d5\u5e73\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u9ad8\u6df1\u5ea6\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u306b\u3088\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u5f8c\u90e8\u5e2f\u72b6\u56de\u306b\u304a\u3051\u308b\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u7b2c\uff12\u56de\u5e83\u5cf6\u5927\u5b66\u8133\u795e\u7d4c\u79d1\u5b66\u30bb\u30df\u30ca\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7410\u670810\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
            18. \u5409\u76db \u667a\u4e16\u3001\u5ddd\u898b \u660c\u53f2\u3001\u718a\u8c37 \u96c4\u592a\u3001\u6e6f\u5143 \u826f\u5b50\u3001\u9ad8\u91ce \u5e79\u4e45\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u30a2\u30d9\u30de\u30b7\u30af\u30ea\u30d6\u306b\u3088\u308b\u7d30\u80de\u5468\u671f\u505c\u6b62\u3068\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\u306e\u95a2\u9023\u89e3\u6790\u3000\u7b2c\uff12\u56de\u5e83\u5cf6\u5927\u5b66\u8133\u795e\u7d4c\u79d1\u5b66\u30bb\u30df\u30ca\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7410\u670810\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
            19. \u7af9\u5185 \u88d5\u5b5d\uff0c\u85e4\u4e95 \u5eb7\u4ecb\uff0c\u5ddd\u898b \u660c\u53f2\uff0c\u6e6f\u5143 \u826f\u5b50\uff0c\u9ad8\u91ce \u5e79\u4e45\uff0c\u5185\u7530 \u5eb7\u96c4\u3000\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304a\u3051\u308b\u7d30\u83cc\u7531\u6765\u30b8\u30da\u30d7\u30c1\u30c9\u304c\u8a98\u767a\u3059\u308b\u81ea\u7136\u514d\u75ab\u6a5f\u69cb\u306e\u89e3\u6790\u3000\u30d5\u30a9\u30fc\u30e9\u30e02023 \u885b\u751f\u85ac\u5b66\u30fb\u74b0\u5883\u30c8\u30ad\u30b7\u30b3\u30ed\u30b8\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7409\u670812\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            20. \u524d\u7530 \u7950\u5e0c\u3001\u5ddd\u898b \u660c\u53f2\uff0c\u6e6f\u5143 \u826f\u5b50\uff0c\u9ad8\u91ce \u5e79\u4e45\uff0c\u5185\u7530 \u5eb7\u96c4\u3000RNA-seq\u89e3\u6790\u3092\u7528\u3044\u305f\u85ac\u7269\u8a98\u767a\u6027EMT\u306b\u95a2\u4e0e\u3059\u308bmiRNA\u306e\u65b0\u898f\u540c\u5b9a\u624b\u6cd5\u306e\u78ba\u7acb\u3000\u30d5\u30a9\u30fc\u30e9\u30e02023 \u885b\u751f\u85ac\u5b66\u30fb\u74b0\u5883\u30c8\u30ad\u30b7\u30b3\u30ed\u30b8\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7409\u670812\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
            21. \u8d64\u4e95 \u7f8e\u6708\uff0c\u5ddd\u898b \u660c\u53f2\uff0c\u6ce2\u5185 \u5b8f\u6597\uff0c\u6e6f\u5143 \u826f\u5b50\uff0c\u9ad8\u91ce \u5e79\u4e45\uff0c\u5c71\u672c \u4f51\u6a39\uff0c\u9ad8\u6a4b \u9675\u5b87\uff0c\u7530\u539f \u6804\u4fca\uff0c\u5185\u7530 \u5eb7\u96c4\u3000\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u306b\u304a\u3051\u308bmiR-34a\u8a98\u767a\u6027\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\u306b\u304a\u3051\u308bp53\u306e\u5f79\u5272\u89e3\u6790\u3000\u30d5\u30a9\u30fc\u30e9\u30e02023 \u885b\u751f\u85ac\u5b66\u30fb\u74b0\u5883\u30c8\u30ad\u30b7\u30b3\u30ed\u30b8\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7409\u670812\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            22. \u798f\u5cf6 \u611b\u68a8\u3001\u5ddd\u898b \u660c\u53f2\u3001\u6749\u5143 \u52c7\u6bc5\u3001\u6e6f\u5143 \u826f\u5b50\u3001\u9ad8\u91ce \u5e79\u4e45\u3001\u5185\u7530 \u5eb7\u96c4\u3000\u4e73\u304c\u3093\u7d30\u80de\u306b\u304a\u3051\u308bRibavirin\u306e\u6297\u816b\u760d\u52b9\u679c\u306b\u5bfe\u3059\u308b\u8010\u6027\u5316\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u30d5\u30a9\u30fc\u30e9\u30e02023 \u885b\u751f\u85ac\u5b66\u30fb\u74b0\u5883\u30c8\u30ad\u30b7\u30b3\u30ed\u30b8\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7409\u670812\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            23. \u85e4\u672c \u5b87\u5b99, \u5ddd\u898b \u660c\u53f2, \u6e6f\u5143 \u826f\u5b50, \u9ad8\u91ce \u5e79\u4e45, \u5185\u7530 \u5eb7\u96c4\u3000A549\u7d30\u80de\u306b\u304a\u3051\u308b\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u306b\u3088\u308bEMT\u8a98\u767a\u3068\u6297\u304c\u3093\u52b9\u679c\u306e\u95a2\u9023\u89e3\u6790\u3000\u30d5\u30a9\u30fc\u30e9\u30e02023 \u885b\u751f\u85ac\u5b66\u30fb\u74b0\u5883\u30c8\u30ad\u30b7\u30b3\u30ed\u30b8\u30fc\u3000\u5e83\u5cf6\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
            24. \u9ad8\u6a4b \u8ad2\uff0c\u5ddd\u898b \u660c\u53f2 \uff0c\u6e6f\u5143 \u826f\u5b50\uff0c\u9ad8\u91ce \u5e79\u4e45\uff0c\u5185\u7530 \u5eb7\u96c4\u3000\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u306b\u304a\u3051\u308b\u4e0a\u76ae\u304a\u3088\u3073\u9593\u8449\u5f62\u8cea\u306b\u53ca\u307c\u3059\u6297\u304c\u3093\u5264\u306e\u5f71\u97ff\u89e3\u6790\u3000\u30d5\u30a9\u30fc\u30e9\u30e02023 \u885b\u751f\u85ac\u5b66\u30fb\u74b0\u5883\u30c8\u30ad\u30b7\u30b3\u30ed\u30b8\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7409\u670812\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
            25. \u6ce2\u6765\u8c37 \u5e0c\u5b9f\uff0c\u5ddd\u898b \u660c\u53f2\uff0c\u6e6f\u5143 \u826f\u5b50\uff0c\u9ad8\u91ce \u5e79\u4e45\uff0c\u5185\u7530 \u5eb7\u96c4\u3000\u57f9\u990a\u7d30\u80de\u7cfb\u306b\u304a\u3051\u308b\u7d30\u80de\u5185pH\u5909\u52d5\u306b\u7740\u76ee\u3057\u305f\u30cb\u30b3\u30c1\u30f3\u8f38\u9001\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u30d5\u30a9\u30fc\u30e9\u30e02023 \u885b\u751f\u85ac\u5b66\u30fb\u74b0\u5883\u30c8\u30ad\u30b7\u30b3\u30ed\u30b8\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7409\u670812\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
            26. \u677e\u5ca1 \u7f8e\u7a7a\uff0c\u5ddd\u898b \u660c\u53f2\uff0c\u6e6f\u5143 \u826f\u5b50\uff0c\u9ad8\u91ce \u5e79\u4e45\uff0c\u5185\u7530 \u5eb7\u96c4\u3000\u80ba\u80de\u4e0a\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3\u306b\u3088\u308b\u30da\u30d7\u30c1\u30c9\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fcPEPT2\u6a5f\u80fd\u306e\u963b\u5bb3\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u30d5\u30a9\u30fc\u30e9\u30e02023 \u885b\u751f\u85ac\u5b66\u30fb\u74b0\u5883\u30c8\u30ad\u30b7\u30b3\u30ed\u30b8\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7409\u670812\u65e5\u3000\u30dd\u30b9\u30bf\u30fc\u767a\u8868<\/li>\n\n
            27. \u4e2d\u897f\u9ebb\u5f25\u3001\u5ddd\u898b\u660c\u53f2\u3001\u6e6f\u5143\u826f\u5b50\u3001\u9ad8\u91ce\u5e79\u4e45\u3001\u5185\u7530\u5eb7\u96c4\u3000\u30d2\u30c8\u80ba\u7531\u6765H441\u7d30\u80de\u306b\u304a\u3051\u308bPEPT2\u306e\u767a\u73fe\u3068AhR\u306e\u95a2\u9023\u89e3\u6790\u3000\u30d5\u30a9\u30fc\u30e9\u30e02023 \u885b\u751f\u85ac\u5b66\u30fb\u74b0\u5883\u30c8\u30ad\u30b7\u30b3\u30ed\u30b8\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7409\u670812\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li>\n\n
            28. \u5409\u76db \u667a\u4e16\uff0c\u5ddd\u898b \u660c\u53f2\uff0c\u718a\u8c37 \u96c4\u592a\uff0c\u6e6f\u5143 \u826f\u5b50 \uff0c\u9ad8\u91ce \u5e79\u4e45\uff0c\u5185\u7530 \u5eb7\u96c4\u3000\u80ba\u80de\u4e0a\u76ae\u306b\u304a\u3051\u308b\u30a2\u30d9\u30de\u30b7\u30af\u30ea\u30d6\u8a98\u767a\u6027\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\u6a5f\u69cb\u306e\u89e3\u660e\u3000\u30d5\u30a9\u30fc\u30e9\u30e02023 \u885b\u751f\u85ac\u5b66\u30fb\u74b0\u5883\u30c8\u30ad\u30b7\u30b3\u30ed\u30b8\u30fc\u3000\u5e83\u5cf6\u30002023\u5e7409\u670812\u65e5\u3000\u53e3\u982d\u767a\u8868<\/li><\/ol>

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