{"id":2,"date":"2024-07-09T02:28:57","date_gmt":"2024-07-09T02:28:57","guid":{"rendered":"https:\/\/uchidalab.hiroshima-u.ac.jp\/?page_id=2"},"modified":"2024-11-03T09:11:29","modified_gmt":"2024-11-03T09:11:29","slug":"research","status":"publish","type":"page","link":"https:\/\/uchidalab.hiroshima-u.ac.jp\/index.php\/research\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"<div class=\"wp-block-cover alignfull is-light\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\" style=\"background-color:#8b8782\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"1479\" height=\"1109\" class=\"wp-block-cover__image-background wp-image-335\" alt=\"\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/07\/Research.jpg\" data-object-fit=\"cover\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/07\/Research.jpg 1479w, 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role=\"button\" aria-pressed=\"true\" target=\"_blank\" rel=\"noopener\"><div class=\"vk_button_link_caption\"><span class=\"vk_button_link_txt\">English<\/span><\/div><\/a><\/div>\n\n<p class=\"has-text-align-center has-large-font-size wp-block-paragraph\"><span data-fontsize=\"60px\" style=\"font-size: 60px;\" class=\"vk_inline-font-size\"><strong>\u7814\u7a76\u5185\u5bb9<\/strong><\/span><\/p><\/div><\/div><p class=\"wp-block-paragraph\" id=\"Research1\"><strong><span data-fontsize=\"24px\" style=\"font-size: 24px;\" class=\"vk_inline-font-size\">\u4e2d\u67a2\u75be\u60a3\u533b\u7642\u306e\u672a\u6765\u3092\u62d3\u304f\u4e2d\u67a2\u95a2\u9580\u5275\u85ac\u5b66\u306e\u5275\u6210<\/span><\/strong><\/p><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><span data-fontsize=\"18px\" style=\"font-size: 18px;\" 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class=\"wp-block-paragraph\"><\/p><div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"885\" height=\"1024\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/4\u3064\u306e\u69cb\u60f3\u306e\u56f3_\u65e5\u672c\u8a9e\u7248_20241015\u66f4\u65b0-885x1024.png\" alt=\"\" class=\"wp-image-622\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/4\u3064\u306e\u69cb\u60f3\u306e\u56f3_\u65e5\u672c\u8a9e\u7248_20241015\u66f4\u65b0-885x1024.png 885w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/4\u3064\u306e\u69cb\u60f3\u306e\u56f3_\u65e5\u672c\u8a9e\u7248_20241015\u66f4\u65b0-259x300.png 259w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/4\u3064\u306e\u69cb\u60f3\u306e\u56f3_\u65e5\u672c\u8a9e\u7248_20241015\u66f4\u65b0-768x888.png 768w, 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https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/4\u3064\u306e\u69cb\u60f3\u306e\u56f3_\u65e5\u672c\u8a9e\u7248_20241015\u66f4\u65b0-1920x2220.png 1920w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/4\u3064\u306e\u69cb\u60f3\u306e\u56f3_\u65e5\u672c\u8a9e\u7248_20241015\u66f4\u65b0.png 1969w\" sizes=\"auto, (max-width: 885px) 100vw, 885px\" \/><\/figure><\/div><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\"><strong>\u69cb\u60f31 \u4e2d\u67a2\u75be\u60a3\u306b\u304a\u3051\u308b\u4e2d\u67a2\u95a2\u9580\u306e\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u3092\u89e3\u660e\u3057\u3001\u4e2d\u67a2\u75be\u60a3\u306e\u767a\u75c7\u30fb\u9032\u884c\u3078\u306e\u5bc4\u4e0e\u3092\u8a3c\u660e\u3057\u307e\u3059\u3002<\/strong>\u6211\u3005\u306e\u5f37\u307f\u306f\u3001\u30de\u30a6\u30b9\u306b\u9650\u3089\u305a\u3001\u30d2\u30c8\u306e\u4e2d\u67a2\u95a2\u9580\u306e\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u3092\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3067\u89e3\u660e\u3059\u308b\u6280\u8853\u3092\u4fdd\u6709\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u3059\u3002\u7279\u306b\u3001\u30d2\u30c8\u306e\u7d44\u7e54\u691c\u4f53\u306f\u3001\u30db\u30eb\u30de\u30ea\u30f3\u56fa\u5b9a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u7db2\u7f85\u7684\u306a\u5206\u5b50\u6a5f\u69cb\u3092\u5b9a\u91cf\u7684\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3068\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u6211\u3005\u306f\u3001\u30db\u30eb\u30de\u30ea\u30f3\u56fa\u5b9a\u30d1\u30e9\u30d5\u30a3\u30f3\u5305\u57cb\u5207\u7247\uff08FFPE\uff09\u306b\u5bfe\u3059\u308b\u9ad8\u7cbe\u5ea6\u306a\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u6280\u8853\u3092\u72ec\u81ea\u306b\u958b\u767a\u3057\u3001\u8133\u5185\u306e\u5404\u4e2d\u67a2\u95a2\u9580\u3092\u30ec\u30fc\u30b6\u30fc\u30de\u30a4\u30af\u30ed\u30c0\u30a4\u30bb\u30af\u30b7\u30e7\u30f3\u3067\u63a1\u53d6\u3057\u3066\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u89e3\u6790\u3092\u5b9f\u65bd\u3057\u3066\u3044\u307e\u3059\u3002\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u89e3\u6790\u3067\u5019\u88dc\u306b\u3042\u304c\u308b\u8cac\u4efb\u5206\u5b50\u3042\u308b\u3044\u306f\u8cac\u4efb\u5206\u5b50\u6a5f\u69cb\u3092\u3001\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a3\u30eb\u30b9\uff08AAV\uff09\u3092\u7528\u3044\u305fin vivo\u907a\u4f1d\u5b50\u5de5\u5b66\u6280\u8853\u3067\u4e2d\u67a2\u95a2\u9580\u7d30\u80de\u9078\u629e\u7684\u306b\u767a\u73fe\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u4e2d\u67a2\u75be\u60a3\u75c5\u614b\u306e\u767a\u75c7\u30fb\u9032\u884c\u3078\u306e\u5bc4\u4e0e\u3092\u8a3c\u660e\u3057\u307e\u3059\u3002<\/span><\/p><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\"><strong>\u69cb\u60f32\u3000\u4ed6\u81d3\u5668\u306b\u6bd4\u3079\u3001\u4e2d\u67a2\u95a2\u9580\u306b\u3001\u3088\u308a\u9ad8\u767a\u73fe\u3059\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u540c\u5b9a\u3057\u3001\u6297\u4f53\u3092\u4f5c\u88fd\u3057\u3001\u53d6\u308a\u8fbc\u307f\u901f\u5ea6\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u305d\u308c\u305e\u308c\u306e\u4e2d\u67a2\u95a2\u9580\u7d30\u80de\u5185\u3078\u52b9\u7387\u3088\u304f\u6297\u4f53\u3092\u9001\u9054\u3059\u308b\u6280\u8853\u3092\u78ba\u7acb\u3057\u307e\u3059\u3002<\/strong>\u6211\u3005\u306e\u5f37\u307f\u306f\u3001\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d76\u5bfe\u767a\u73fe\u91cf\uff08mole\uff09\u3092\u7db2\u7f85\u7684\u304b\u3064\u9ad8\u7cbe\u5ea6\u306b\u5b9a\u91cf\u3059\u308b\u6280\u8853\uff08quantitative Global Absolute Proteomics\uff08qGAP\u6cd5\uff09\uff09\u3092\u958b\u767a\u3057\u3066\u3044\u308b\u70b9\u3067\u3059\u3002\u3053\u306e\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u4e2d\u67a2\u95a2\u9580\u7d30\u80de\u306e\u8840\u6db2\u5074\u7d30\u80de\u819c\u306b\u5c40\u5728\u3059\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d76\u5bfe\u767a\u73fe\u91cf\u3092\u7db2\u7f85\u7684\u306b\u89e3\u660e\u3057\u3001\u4ed6\u81d3\u5668\u306b\u6bd4\u3079\u3066\u5404\u4e2d\u67a2\u95a2\u9580\u306b\u9078\u629e\u7684\u306b\u9ad8\u767a\u73fe\u3059\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9078\u629c\u3057\u307e\u3059\u3002\u5019\u88dc\u306e\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d30\u80de\u5916\u9818\u57df\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u4f5c\u88fd\u3057\u3001\u8907\u6570\u306e\u6297\u4f53\u5019\u88dc\u306e\u4e2d\u304b\u3089\u3001\u6700\u3082\u9ad8\u901f\u306b\u4e2d\u67a2\u95a2\u9580\u7d30\u80de\u5185\u3078\u53d6\u308a\u8fbc\u307e\u308c\u308b\u6297\u4f53\u3092\u540c\u5b9a\u3057\u307e\u3059\u3002<\/span><\/p><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\"><strong>\u69cb\u60f33\u3000\u4e2d\u67a2\u95a2\u9580\u3092\u6a19\u7684\u3068\u3059\u308b\u4e2d\u67a2\u75be\u60a3\u6cbb\u7642\u306e\u6709\u52b9\u6027\u3092\u5b9f\u8a3c\u3057\u307e\u3059\u3002<\/strong>\u6211\u3005\u306e\u5f37\u307f\u306f\u3001\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\uff08\u75c5\u614b\u306b\u304a\u3051\u308b\u69d8\u3005\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u91cf\u306e\u5909\u5316\uff09\u3092\u6b63\u5e38\u5316\u3067\u304d\u308b\u4f4e\u5206\u5b50\u85ac\u304a\u3088\u3073\u6838\u9178\u306e\u914d\u5217\uff08miRNA, ASO, siRNA\uff09\u3092\u4e88\u6e2c\u3067\u304d\u308b\u72ec\u81ea\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u958b\u767a\u3057\u3066\u3044\u308b\u70b9\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u5f93\u6765\u306e\u6cbb\u7642\u7528miRNA\u914d\u5217\u306e\u4e88\u6e2c\u6cd5\u306f\u3001\u75c5\u614b\u6642\u306b\u304a\u3051\u308b\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u3066\u3001\u75c5\u614b\u3092\u6b63\u5e38\u5316\u3067\u304d\u308b\u3068\u4e88\u60f3\u3055\u308c\u308bmiRNA\u914d\u5217\u3092\u9078\u3076\u3082\u306e\u3067\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u30ec\u30d9\u30eb\u306e\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u3092\u5341\u5206\u306b\u6b63\u5e38\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001\u6211\u3005\u304c\u958b\u767a\u3057\u305f\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u300cmiR-PAIR\u6cd5\u300d\u306f\u3001\u75c5\u614b\u306b\u76f4\u7d50\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u7fa4\u306e\u5206\u5b50\u6a5f\u69cb\u3092\u6b63\u5e38\u5316\u3067\u304d\u308bmiRNA\u914d\u5217\u3092\u4e88\u6e2c\u3067\u304d\u308b\u3082\u306e\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u69cb\u60f31\u3067\u89e3\u660e\u3055\u308c\u308b\u4e2d\u67a2\u95a2\u9580\u306e\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u3092\u6b63\u5e38\u5316\u3067\u304d\u308b\u4f4e\u5206\u5b50\u85ac\u3001miRNA\u3001ASO\/siRNA\u3092\u9078\u629c\u3057\uff08\u6838\u9178\u306f\u69cb\u60f32\u306e\u6297\u4f53\u3068\u306e\u8907\u5408\u4f53\u3092\u4f5c\u3063\u3066\uff09\u3001\u75be\u60a3\u30e2\u30c7\u30eb\u52d5\u7269\u306b\u6295\u4e0e\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u4e2d\u67a2\u75be\u60a3\u75c5\u614b\u3092\u6cbb\u7642\u3067\u304d\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u307e\u3059\u3002<\/span><\/p><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\"><strong>\u69cb\u60f34<\/strong>\u3000<strong>\u4e2d\u67a2\u95a2\u9580\u306e\u72b6\u614b\u3092\u8a08\u6e2c\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u8133\u5185\u74b0\u5883\uff08\u4e2d\u67a2\u75be\u60a3\uff09\u3092\u8a3a\u65ad\u3059\u308b\u4ed5\u7d44\u307f\u3092\u4f5c\u308a\u307e\u3059\u3002<\/strong>\u69cb\u60f32\u3067\u958b\u767a\u3059\u308b\u6297\u4f53\u306b\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u3092\u4fee\u98fe\u3057\u3001\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001\u4e2d\u67a2\u95a2\u9580\u5185\u306b\u8a3a\u65ad\u30d7\u30ed\u30fc\u30d6\u3092\u5c0e\u5165\u3067\u304d\u3001\u4e2d\u67a2\u95a2\u9580\u306e\u74b0\u5883\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u8133\u5185\u3068\u4e2d\u67a2\u95a2\u9580\u306f\u4e92\u3044\u306b\u5f71\u97ff\u3057\u5408\u3046\u95a2\u4fc2\u3067\u3042\u308b\u305f\u3081\u3001\u8133\u5185\u306e\u7570\u5e38\u306f\u3001\u4e2d\u67a2\u95a2\u9580\u306b\u73fe\u308c\u307e\u3059\u3002\u8a3a\u65ad\u30d7\u30ed\u30fc\u30d6\u306b\u3088\u3063\u3066\u753b\u50cf\u8a3a\u65ad\u3059\u308b\u65b9\u6cd5\u306b\u52a0\u3048\u3066\u3001\u4e2d\u67a2\u95a2\u9580\u304b\u3089\u8840\u6db2\u4e2d\u306b\u6f0f\u51fa\u3059\u308b\u75be\u60a3\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u8840\u6db2\u8a3a\u65ad\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u4e2d\u67a2\u75be\u60a3\u306e\u65b0\u305f\u306a\u8a3a\u65ad\u57fa\u76e4\u300c\u4e2d\u67a2\u95a2\u9580\u8a3a\u65ad\u300d\u3092\u78ba\u7acb\u3057\u307e\u3059\u3002<\/span><\/p><div style=\"height:54px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\" id=\"Research2\"><strong><span data-fontsize=\"21px\" style=\"font-size: 21px;\" class=\"vk_inline-font-size\">claudin-5\u306b\u7740\u76ee\u3057\u305f\u7814\u7a76\uff08\u6a4b\u672c\u30b0\u30eb\u30fc\u30d7\uff09<\/span><\/strong><\/p><p class=\"wp-block-paragraph\">\u6a4b\u672c\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u5185\u7530\u30b0\u30eb\u30fc\u30d7\u304c\u63d0\u5531\u3059\u308b4\u5927\u4e2d\u67a2\u95a2\u9580\u306e\u5185\u3001\u8840\u6db2\u8133\u95a2\u9580\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u8840\u6db2\u8133\u95a2\u9580\u3092\u69cb\u6210\u3059\u308b\u8133\u5185\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u5b58\u5728\u3059\u308b\u5bc6\u7740\u7d50\u5408\u3068\u3001\u305d\u306e\u5bc6\u7740\u7d50\u5408\u3092\u69cb\u6210\u3059\u308bclaudin-5 (CLDN-5) \u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7740\u76ee\u3057\u3066\u3044\u307e\u3059\u3002<\/p><div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"331\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research5-1024x331.png\" alt=\"\" class=\"wp-image-618\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research5-1024x331.png 1024w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research5-300x97.png 300w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research5-768x248.png 768w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research5-500x161.png 500w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research5-800x258.png 800w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research5-1280x413.png 1280w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research5.png 1446w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u5bc6\u7740\u7d50\u5408\u306f\u3001\u96a3\u308a\u5408\u3044\u3001\u300c\u63a5\u7740\u300d\u3057\u305f\u4e0a\u76ae\u7d30\u80de\u3084\u5185\u76ae\u7d30\u80de\u306b\u3001\u7269\u7406\u7684\u306b\u7d30\u80de\u819c\u304c\u878d\u5408\u3059\u308b\u300c\u5bc6\u7740\u300d\u3092\u5f62\u6210\u3055\u305b\u307e\u3059\u3002\u3053\u306e\u300c\u5bc6\u7740\u300d\u306e\u90e8\u5206\u3067\u3001\u5206\u5b50\u3084\u30a4\u30aa\u30f3\u306e\u7d30\u80de\u9593\u9699\u3067\u306e\u52d5\u304d\u3092\u5236\u9650\u3057\u3066\u3044\u307e\u3059\u3002\u5bc6\u7740\u7d50\u5408\u306f\u3001\u30d2\u30c8\u3067\u306f26\u7a2e\u985e\u3042\u308bCLDN family members\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002\u305d\u308c\u305e\u308c\u306eCLDNs\u304c\u3001\u7570\u306a\u308b\u6027\u8cea\u306e\u5bc6\u7740\u7d50\u5408\u3092\u4f5c\u308b\u6027\u8cea\u3001\u3082\u3057\u304f\u306f\u3001\u5bc6\u7740\u7d50\u5408\u306e\u5f62\u614b\u306a\u3069\u3092\u5236\u5fa1\u3059\u308b\u6027\u8cea\u3092\u6709\u3057\u3001\u304b\u3064\u3001\u7570\u306a\u308b\u7d44\u7e54\u30fb\u7d30\u80de\u7279\u7570\u6027\u3092\u6301\u3063\u3066\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002CLDN-5\u3067\u4e3b\u306b\u69cb\u6210\u3055\u308c\u308b\u8133\u5185\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u5bc6\u7740\u7d50\u5408\u306f\u3001\u5206\u5b50\u3084\u30a4\u30aa\u30f3\u306e\u7d30\u80de\u9593\u9699\u306e\u900f\u904e\u3092\u8a31\u5bb9\u3057\u307e\u305b\u3093\u304c\u3001CLDN-15\u3092\u591a\u304f\u542b\u3080\u5c0f\u8178\u4e0a\u76ae\u7d30\u80de\u306e\u5bc6\u7740\u7d50\u5408\u306f\u3001\u967d\u30a4\u30aa\u30f3\u3092\u900f\u904e\u3057\u3084\u3059\u3044\u3068\u3044\u3046\u6027\u8cea\u3092\u6301\u3061\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5bc6\u7740\u7d50\u5408\u306b\u7570\u5e38\u304c\u73fe\u308c\u308b\u3068\u3001\u7d44\u7e54\u5185\u306e\u6052\u5e38\u6027\u304c\u4e71\u308c\u3001\u69d8\u3005\u306a\u75be\u60a3\u304c\u73fe\u308c\u307e\u3059\u3002\u7279\u306b\u3001CLDN-5\u306e\u6a5f\u80fd\u3084\u767a\u73fe\u306b\u7570\u5e38\u304c\u73fe\u308c\u305f\u5834\u5408\u3001\u3066\u3093\u304b\u3093\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3001\u3046\u3064\u30fb\u4e0d\u5b89\u69d8\u75c7\u72b6\u306a\u3069\u306e\u5f15\u304d\u91d1\u306b\u306a\u308a\u307e\u3059\u3002\u52a0\u3048\u3066\u3001\u3053\u308c\u3089\u3092\u542b\u3080\u591a\u304f\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u6162\u6027\u5ea6\u3084\u91cd\u75c7\u5ea6\u3092\u9593\u63a5\u7684\u306b\u9ad8\u3081\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\u306e\u6a4b\u672c\u306f\u3001\u4e16\u754c\u3067\u521d\u3081\u3066\u30d2\u30c8\u3067\u75be\u60a3\u3092\u8a98\u5c0e\u3059\u308bCLDN-5\u306e\u907a\u4f1d\u5b50\u5909\u7570\u4f53\u3092\u5831\u544a\u3010<a href=\"https:\/\/doi.org\/10.1093\/brain\/awac215\">https:\/\/doi.org\/10.1093\/brain\/awac215<\/a>\u3011\u3057\u305f\u308a\u3001CLDN-5\u306e\u6a5f\u80fd\u3092\u4e2d\u548c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u4e16\u754c\u521d\u306eCLDN-5\u306b\u5bfe\u3059\u308b\u6297\u4f53\u306e\u5275\u88fd\u3010<a href=\"https:\/\/doi.org\/10.1124\/jpet.117.243014\">https:\/\/doi.org\/10.1124\/jpet.117.243014<\/a>\u3011\u3092\u884c\u3063\u3066\u304d\u305f\u308a\u3068\u3001CLDN-5\u306b\u7279\u5316\u3057\u305f\u7814\u7a76\u3092\u884c\u3063\u3066\u304d\u3066\u304a\u308a\u307e\u3059\u3002<\/span><\/p><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u6a4b\u672c\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001CLDN-5\u306e\u300c\u6a5f\u80fd\u300d\u30fb\u300c\u767a\u73fe\u300d\u306e\u7570\u5e38\u3092\u5143\u306b\u623b\u3059\u300c\u4e2d\u67a2\u8840\u7ba1\u306e\u6cbb\u7642\u300d\u306b\u3088\u3063\u3066\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u6cbb\u7642\u304c\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\uff1f\u3092\u4e2d\u5fc3\u30c6\u30fc\u30de\u306b\u3001<\/span><\/p><ul class=\"wp-block-list\"><li><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059CLDN-5\u306e\u4e2d\u548c\u306b\u3088\u308b\u300c\u6a5f\u80fd\u300d\u306e\u6b63\u5e38\u5316<\/span><\/li>\n\n<li><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u75be\u60a3\u6642\u306bCLDN-5\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3088\u3046\u306b\u767a\u73fe\u4e0a\u6607\u3059\u308b\u907a\u4f1d\u5b50\u306e\u963b\u5bb3\u306b\u3088\u308bCLDN-5\u306e\u300c\u767a\u73fe\u91cf\u300d\u306e\u6b63\u5e38\u5316<\/span><\/li><\/ul><p class=\"wp-block-paragraph\"><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u3092\u3001\u4e0b\u8a18\u5b9f\u9a13\u30c4\u30fc\u30eb\u3092\u4f7f\u3044\u3064\u3064\u3001\u56fd\u5185\u5916\u306e\u69d8\u3005\u306a\u8840\u6db2\u8133\u95a2\u9580\u3092\u7814\u7a76\u3059\u308b\u30c1\u30fc\u30e0\u3068\u9023\u643a\u3057\u306a\u304c\u3089\u884c\u3063\u3066\u3044\u304d\u307e\u3059\u3002<\/span><\/p><ul class=\"wp-block-list\"><li><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\uff08\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3084CLDN-5\u767a\u73fe\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306bGFP\u3092\u767a\u73fe\u3059\u308b\u30de\u30a6\u30b9\uff09<\/span><\/li>\n\n<li><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u907a\u4f1d\u5b50\u6539\u5909\u30e2\u30c7\u30eb\u7d30\u80de\uff08\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\u3084\u30ec\u30c8\u30ed\u69d8\u30a6\u30a4\u30eb\u30b9\u3092\u4f7f\u7528\u3057\u305f\u907a\u4f1d\u5b50\u306e\u904e\u5270\u767a\u73fe\u3001CRISPR\/Cas9\u3092\u4f7f\u7528\u3057\u305f\u907a\u4f1d\u5b50\u306e\u6b20\u640d\uff09<\/span><\/li>\n\n<li><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u6297\u4f53\uff08\u514d\u75ab\u6cd5\u306b\u3088\u308b\u6297\u4f53\u306e\u4f5c\u88fd\u3001\u6297\u4f53\u5de5\u5b66\u306b\u3088\u308b\u6a5f\u80fd\u6539\u5909\u3002\u8840\u6db2\u8133\u95a2\u9580\u3078\u306e\u6a19\u7684\u5316\uff09<\/span><\/li>\n\n<li><span data-fontsize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u8840\u6db2\u8133\u95a2\u9580\u6a21\u5023\u7cfb\uff08\u6d77\u5916\u306e\u5171\u540c\u7814\u7a76\u8005\u304b\u3089\u5c0e\u5165\u4e88\u5b9a\u3002\u3002\u3002\uff09<\/span><\/li><\/ul><div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"258\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research6-1024x258.png\" alt=\"\" class=\"wp-image-628\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research6-1024x258.png 1024w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research6-300x75.png 300w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research6-768x193.png 768w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research6-500x126.png 500w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research6-800x201.png 800w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research6-1280x322.png 1280w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/10\/Research6.png 1316w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div><div style=\"height:66px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div><p class=\"wp-block-paragraph\" id=\"Research3\"><strong><span data-fontsize=\"21px\" style=\"font-size: 21px;\" class=\"vk_inline-font-size\">\u30d2\u30c8\u306e\u751f\u4f53\u5185\u3067\u75c5\u6c17\u306e\u7d44\u7e54\u306b\u304a\u3051\u308b\u5206\u5b50\u6a5f\u69cb\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3069\u306e\u3088\u3046\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u5fc5\u8981\u304b\uff1f<\/span><\/strong><\/p><p class=\"wp-block-paragraph\"><span data-fontSize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u5275\u85ac\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u30d2\u30c8\u306e\u751f\u4f53\u5185\u3067\u8d77\u3053\u3063\u3066\u3044\u308b\u75be\u60a3\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u3001\u305d\u308c\u3092\u7406\u89e3\u3057\u305f\u3046\u3048\u3067\u65b0\u85ac\u958b\u767a\u3092\u884c\u3046\u3053\u3068\u304c\u738b\u9053\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30d2\u30c8\u306e\u75c5\u614b\u7d44\u7e54\uff08\u65b0\u9bae\u3001\u51cd\u7d50\u306e\u7d44\u7e54\uff09\u3092\u5341\u5206\u91cf\u5165\u624b\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3059\u3002\u30db\u30eb\u30de\u30ea\u30f3\u56fa\u5b9a\u3057\u305f\u30d2\u30c8\u75c5\u614b\u7d44\u7e54\uff08\u30db\u30eb\u30de\u30ea\u30f3\u56fa\u5b9a\u30d1\u30e9\u30d5\u30a3\u30f3\u5305\u57cb\u7d44\u7e54\uff1bFormalin Fixed Paraffin Embedded\uff08FFPE\uff09tissue\uff09\u306f\u533b\u7642\u6a5f\u95a2\u306b\u305f\u304f\u3055\u3093\u4fdd\u7ba1\u3055\u308c\u3066\u304a\u308a\u3001\u5927\u5909\u9b45\u529b\u7684\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u73fe\u72b6\u306f\u75c5\u7406\u8a3a\u65ad\u306e\u7528\u9014\u306b\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u306e\u76ee\u7684\u306b\u306f\u5229\u7528\u3067\u304d\u306a\u3044\u3001\u306a\u3069\u3068\u3044\u3046\u5927\u304d\u306a\u8ab2\u984c\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u305f\u3081\u3001\u75be\u60a3\u30e2\u30c7\u30eb\u52d5\u7269\u30fb\u57f9\u990a\u7d30\u80de\u306a\u3069\u3092\u7528\u3044\u305f\u5b9f\u9a13\u7cfb\u304c\u5e45\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u304d\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u30e2\u30c7\u30eb\u306f\u30d2\u30c8\u306e\u771f\u306e\u75c5\u614b\u3092\u53cd\u6620\u3057\u3066\u3044\u306a\u3044\u3068\u3044\u3046\u6839\u672c\u7684\u306a\u554f\u984c\u3092\u62b1\u3048\u3066\u3044\u307e\u3059\u3002<\/span><\/p><p class=\"wp-block-paragraph\"><span data-fontSize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u6211\u3005\u306f\u3001\u76f4\u63a5\u7684\u306b\u30d2\u30c8\u306e\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u30d2\u30c8\u306e\u75c5\u614b\u7d44\u7e54\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u304c\u5fc5\u9808\u3067\u3042\u308b\u3068\u8003\u3048\u3001\u533b\u7642\u6a5f\u95a2\u306b\u8c4a\u5bcc\u306b\u4fdd\u7ba1\u3055\u308c\u3066\u3044\u308b\u300cFFPE\u7d44\u7e54\u300d\u306e\u5229\u7528\u304c\u6700\u3082\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u307e\u3057\u305f\u3002<\/span><\/p><p class=\"wp-block-paragraph\"><span data-fontSize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">FFPE\u7d44\u7e54\u306b\u5bfe\u3057\u3066\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u6280\u8853\u3092\u9069\u7528\u3067\u304d\u308c\u3070\u3001\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306e\u7a81\u7834\u53e3\u304c\u958b\u304b\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001FFPE\u7d44\u7e54\u5185\u3067\u306f\u3001\u3042\u3089\u3086\u308b\u751f\u4f53\u5206\u5b50\u306f\u3001\u30db\u30eb\u30de\u30ea\u30f3\u67b6\u6a4b\u306b\u3088\u3063\u3066\u4e92\u3044\u306b\u5bc6\u306b\u5171\u6709\u7d50\u5408\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u5f93\u6765\u6cd5\u3067\u306f\u3001FFPE\u7d44\u7e54\u304b\u3089\u52b9\u7387\u3088\u304f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u62bd\u51fa\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3057\u305f\u3002\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001\u6211\u3005\u306f\u3001\u8d85\u9ad8\u5727\u3001\u9ad8\u6e29\u304a\u3088\u3073\u5f37\u529b\u306a\u53ef\u6eb6\u5316\u5264\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001FFPE\u7d44\u7e54\u304b\u3089\u9ad8\u52b9\u7387\u3067\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u62bd\u51fa\u304c\u56f0\u96e3\u306a\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3082\uff09\u3092\u62bd\u51fa\u3067\u304d\u308b\u65b9\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u9ad8\u7cbe\u5ea6\u306a\u7db2\u7f85\u7684\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u6280\u8853\uff08SWATH\u6cd5\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u7d44\u7e54\u304b\u3089\u306e\u30bf\u30f3\u30d1\u30af\u62bd\u51fa\u304b\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5b9a\u91cf\u307e\u3067\u306e\u4e00\u9023\u306e\u904e\u7a0b\u3092\u9ad8\u7cbe\u5ea6\u5316\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u3059\u306a\u308f\u3061\u3001\u751f\u4f53\u5185\u3067\u751f\u3058\u3066\u3044\u308b\u5206\u5b50\u6a5f\u69cb\u3092\u305d\u306e\u307e\u307e\u4e38\u3054\u3068\uff08\u30ed\u30b9\u306a\u304f\uff09\u62bd\u51fa\u3067\u304d\u3001\u5b9a\u91cf\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u305f\u3081\u3001\u75c5\u614b\u3068\u6b63\u5e38\u306eFFPE\u7d44\u7e54\u3092\u7528\u3044\u3066\u5f97\u3089\u308c\u305f\u5404\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u75c5\u614b\u5909\u5316\u7387\uff08\u75c5\u614b\/\u6b63\u5e38\u6bd4\uff09\u304c\u3001\u751f\u4f53\u5185\uff08\u65b0\u9bae\u7d44\u7e54\uff09\u306e\u75c5\u614b\u5909\u5316\u7387\u3092\u6975\u3081\u3066\u826f\u597d\u306b\u53cd\u6620\u3059\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u4e0b\u56f3\u306e\u5f93\u6765\u6cd5\u306e\u30b0\u30e9\u30d5\u3068\u6bd4\u3079\u308b\u3068\u4e00\u76ee\u77ad\u7136\u3067\u3059\u3002<\/span><\/p><p class=\"wp-block-paragraph\"><span data-fontSize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u4e16\u754c\u4e2d\u306e\u533b\u7642\u6a5f\u95a2\u306b\u306f\u3001\u81a8\u5927\u306a\u6570\u306eFFPE\u7d44\u7e54\u304c\u81e8\u5e8a\u60c5\u5831\u3068\u7d10\u3065\u3044\u3066\u4fdd\u7ba1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f93\u3063\u3066\u3001\u4e0b\u56f3\u306e\u3088\u3046\u306b\u3001\u3042\u308b\u75be\u60a3\u306b\u3064\u3044\u3066\u3001\u8907\u6570\u306e\u60a3\u8005\u306eFFPE\u7d44\u7e54\u691c\u4f53\u3092\u51e6\u7406\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u75be\u60a3\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5168\u5bb9\u304c\u89e3\u660e\u3055\u308c\u3001\u65b0\u85ac\u958b\u767a\u306e\u65b0\u305f\u306a\u6a19\u7684\u5206\u5b50\u30fb\u30d1\u30b9\u30a6\u30a7\u30a4\u306e\u767a\u898b\u306b\u3064\u306a\u304c\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u60a3\u8005\u3054\u3068\u306e\u75c5\u614b\u5206\u5b50\u6a5f\u69cb\u306e\u8a3a\u65ad\u306b\u57fa\u3065\u304f\u3001\u30aa\u30fc\u30c0\u30fc\u30e1\u30a4\u30c9\u533b\u7642\u3078\u306e\u5fdc\u7528\u3082\u8996\u91ce\u306b\u5165\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p><div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\"><div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1011\" height=\"748\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research1.png\" alt=\"\" class=\"wp-image-845\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research1.png 1011w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research1-300x222.png 300w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research1-768x568.png 768w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research1-500x370.png 500w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research1-800x592.png 800w\" sizes=\"auto, (max-width: 1011px) 100vw, 1011px\" \/><\/figure><\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1011\" height=\"753\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research2.png\" alt=\"\" class=\"wp-image-846\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research2.png 1011w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research2-300x223.png 300w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research2-768x572.png 768w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research2-500x372.png 500w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research2-800x596.png 800w\" sizes=\"auto, (max-width: 1011px) 100vw, 1011px\" \/><\/figure><\/div><\/div><div style=\"height:66px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div><p class=\"wp-block-paragraph\" id=\"Research4\"><strong><span data-fontsize=\"21px\" style=\"font-size: 21px;\" class=\"vk_inline-font-size\">\u65b0\u305f\u306a\u4e2d\u67a2\u95a2\u9580\uff08\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580\uff09\u306e\u5f79\u5272\u3092\u89e3\u660e\uff01<\/span><\/strong><\/p><div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\"><div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><p class=\"wp-block-paragraph\"><span data-fontSize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u4e2d\u67a2\u306e\u95a2\u9580\u3068\u3044\u3048\u3070\u3001\u8840\u6db2\u8133\u95a2\u9580\u304c\u826f\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u4ee5\u5916\u306b\u3082\u8907\u6570\u306e\u95a2\u9580\u7d44\u7e54\u304c\u53e4\u304f\u304b\u3089\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u6a5f\u80fd\u3084\u5f79\u5272\u306f\u4e0d\u660e\u306a\u3082\u306e\u304c\u591a\u3044\u3067\u3059\u3002\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580\u306f\u3001\u4e2d\u67a2\u7d44\u7e54\u306e\u5916\u5468\u3001\u5177\u4f53\u7684\u306b\u306f\u8133\u810a\u9ac4\u6db2\u306e\u5916\u5074\u3092\u8986\u3046\u95a2\u9580\u7d44\u7e54\u3067\u3059\u3002\u5b9f\u614b\u306f\u3001\u30af\u30e2\u819c\u4e0a\u76ae\u7d30\u80de\uff08Arachnoid Epithelial Cell\uff09\u304c\u4e92\u3044\u306b\u5bc6\u7740\u7d50\u5408\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u8133\u810a\u9ac4\u6db2\uff08\u4e2d\u67a2\uff09\u5074\u3068\u5faa\u74b0\u8840\u6db2\uff08\u672b\u68a2\uff09\u5074\u3092\u9694\u3066\u3066\u3044\u307e\u3059\u3002\u65e7\u6765\u306f\u3001\u5358\u306a\u308b\u7269\u8cea\u900f\u904e\u306e\u969c\u58c1\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u6211\u3005\u306f\u3001\u7db2\u7f85\u7684\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u3053\u306e\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580\u306b\u69d8\u3005\u306a\u7a2e\u985e\u306e\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3001\u53d7\u5bb9\u4f53\u3084\u9175\u7d20\u7fa4\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u4e00\u6319\u306b\u89e3\u660e\u3057\u3001\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580\u306e\u56f3\u306b\u793a\u3057\u305f\u3088\u3046\u306a\u69d8\u3005\u306a\u5f79\u5272\u3092\u3082\u3064\u30e6\u30cb\u30fc\u30af\u306a\u95a2\u9580\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3057\u305f\u3002\u30d2\u30c8\u306e\u8840\u6db2\u8133\u95a2\u9580\u3067\u306f\u3001\u6709\u6a5f\u30ab\u30c1\u30aa\u30f3\u6027\u85ac\u7269\u304a\u3088\u3073\u6709\u6a5f\u30a2\u30cb\u30aa\u30f3\u6027\u85ac\u7269\u3092\u8f38\u9001\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u7fa4\u306f\u3001\u8ed2\u4e26\u307f\u691c\u51fa\u9650\u754c\u4ee5\u4e0b\u306e\u4f4e\u3044\u767a\u73fe\u91cf\u3067\u3059\u304c\u3001\u8840\u6db2\u30af\u30e2\u819c\u95a2\u9580\u306f\u56f3\u793a\u3059\u308b\u3088\u3046\u306a\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3092\u9ad8\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u85ac\u7269\u4ee3\u8b1d\u9175\u7d20\u3082\u8c4a\u5bcc\u3067\u3042\u308a\u3001\u4e2d\u67a2\u306e\u85ac\u7269\u52d5\u614b\u3092\u8003\u3048\u308b\u3046\u3048\u3067\u306f\u3001\u7121\u8996\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u30e6\u30cb\u30fc\u30af\u306a\u95a2\u9580\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/span><\/p><\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1013\" height=\"759\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research3.png\" alt=\"\" class=\"wp-image-847\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research3.png 1013w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research3-300x225.png 300w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research3-768x575.png 768w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research3-500x375.png 500w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research3-800x599.png 800w\" sizes=\"auto, (max-width: 1013px) 100vw, 1013px\" \/><\/figure><\/div><\/div><div style=\"height:66px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div><p class=\"wp-block-paragraph\" id=\"Research5\"><strong><span data-fontsize=\"21px\" style=\"font-size: 21px;\" class=\"vk_inline-font-size\">\u65e2\u5b58\u306e\u85ac\u5264\u5b66\u306e\u67a0\u3092\u8d85\u3048\u305f\u7814\u7a76\u3092\u76ee\u6307\u3057\u3066<\/span><\/strong><\/p><p class=\"wp-block-paragraph\"><span data-fontSize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u85ac\u52b9\u3084\u85ac\u7269\u52d5\u614b\u306a\u3069\u3001\u65e2\u5b58\u306e\u5206\u5b50\u3067\u306f\u8aac\u660e\u3067\u304d\u306a\u3044\u73fe\u8c61\u304c\u305f\u304f\u3055\u3093\u3042\u308a\u307e\u3059\u3002\u5f93\u6765\u306e\u65e2\u5b58\u306e\u5206\u5b50\u306b\u7126\u70b9\u3092\u5f53\u3066\u308b\u7814\u7a76\u3067\u306f\u85ac\u5b66\u7814\u7a76\u306e\u7a81\u7834\u53e3\u3092\u62d3\u304f\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u672a\u89e3\u660e\u306e\u5206\u5b50\u6a5f\u69cb\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306e\u6709\u671b\u306a\u6280\u8853\u3068\u3057\u3066\u3001\u6211\u3005\u306f\u3001\u7db2\u7f85\u7684\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u6cd5\uff08\u7db2\u7f85\u7684\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u3092\u63a2\u7d22\u3057\u3001\u5b9a\u91cf\u3059\u308b\u6280\u8853\uff09\u3092\u7528\u3044\u3066\u3044\u307e\u3059\u3002<\/span><\/p><p class=\"wp-block-paragraph\"><span data-fontSize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u5f53\u7814\u7a76\u5ba4\u3067\u7528\u3044\u3066\u3044\u308b\u65b9\u6cd5\u306e\u4e00\u3064\u3067\u3042\u308bSWATH\u6cd5\u306f\u3001\u5f93\u6765\u578b\u306e\u30b7\u30e7\u30c3\u30c8\u30ac\u30f3\u6cd5\u306b\u6bd4\u3079\u3066\u3001\u5b9a\u91cf\u7cbe\u5ea6\u304c\u98db\u8e8d\u7684\u306b\u6539\u5584\u3057\u3001\u3055\u3089\u306b\u3088\u308a\u5c11\u306a\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u307e\u3067\u5b9a\u91cf\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u6280\u8853\u3067\u3059\u3002\u7d50\u679c\u3068\u3057\u3066\u3001\u3088\u308a\u591a\u304f\u306e\u7a2e\u985e\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9ad8\u3044\u7cbe\u5ea6\u3067\u5b9a\u91cf\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u6211\u3005\u306f\u3001\u72ec\u81ea\u306b\u3001SWATH\u6cd5\u3092\u6539\u826f\u3057\u3001quantitative Global Absolute Proteomics (qGAP\u6cd5)\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u901a\u5e38\u306e\u7db2\u7f85\u7684\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u6cd5\u306f\u30012\u7fa4\u9593\u3084\u8907\u6570\u7fa4\u9593\u3067\u306e\u76f8\u5bfe\u5b9a\u91cf\uff08\u500b\u3005\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5b58\u5728\u91cf\u304c\u3001\u3042\u308b\u7fa4\u306b\u6bd4\u3079\u3066\u4ed6\u306e\u7fa4\u3067\u4f55\u500d\u7570\u306a\u308b\u304b\u3092\u5b9a\u91cf\u3059\u308b\u65b9\u6cd5\uff09\u304c\u4e3b\u6d41\u3067\u3059\u3002qGAP\u6cd5\u306f\u3001\u3053\u306e\u76f8\u5bfe\u5b9a\u91cf\u306b\u52a0\u3048\u3066\u3001\u500b\u3005\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d76\u5bfe\u5b58\u5728\u91cf\uff08mole\uff09\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u70b9\u3067\u512a\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p><p class=\"wp-block-paragraph\"><span data-fontSize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u5275\u85ac\u3067\u306f\u3001\u75c5\u614b\u306e\u7d44\u7e54\u3084\u7d30\u80de\u306b\u304a\u3044\u3066\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u30d1\u30b9\u30a6\u30a7\u30a4\u304c\u6700\u3082\u6709\u671b\u306a\u5275\u85ac\u6a19\u7684\u5206\u5b50\u306b\u306a\u308b\u304b\u3092\u8003\u3048\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5b58\u5728\u91cf\u304c\u5927\u304d\u3044\u307b\u3069\u6709\u671b\u3067\u3042\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u85ac\u7269\u52d5\u614b\u306e\u89b3\u70b9\u3067\u306f\u3001\u4f8b\u3048\u3070\u3001\u4e2d\u67a2\u306e\u95a2\u9580\u3067\u9ad8\u767a\u73fe\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3092\u540c\u5b9a\u3067\u304d\u308c\u3070\u3001\u4e2d\u67a2\u7d44\u7e54\u3078\u85ac\u7269\u3092\u52b9\u7387\u3088\u304f\u5c4a\u3051\u308b\u30eb\u30fc\u30c8\u304c\u958b\u304b\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u76ee\u7684\u306b\u9650\u3089\u305a\u3001\u7db2\u7f85\u7684\u306b\u7d76\u5bfe\u5b58\u5728\u91cf\u3092\u6c7a\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u6280\u8853\u306f\u3001\u3042\u3089\u3086\u308b\u30e9\u30a4\u30d5\u30b5\u30a4\u30a8\u30f3\u30b9\u7814\u7a76\u306e\u5834\u306b\u304a\u3044\u3066\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/span><\/p><div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1011\" height=\"754\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research4.png\" alt=\"\" class=\"wp-image-848\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research4.png 1011w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research4-300x224.png 300w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research4-768x573.png 768w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research4-500x373.png 500w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research4-800x597.png 800w\" sizes=\"auto, (max-width: 1011px) 100vw, 1011px\" \/><\/figure><\/div><div style=\"height:66px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div><p class=\"wp-block-paragraph\" id=\"Research6\"><strong><span data-fontsize=\"21px\" style=\"font-size: 21px;\" class=\"vk_inline-font-size\">\u30d2\u30c8\u306e\u8133\u3078\u306e\u85ac\u7269\u79fb\u884c\u6027\u3092\u5b9a\u91cf\u7684\u306b\u6b63\u78ba\u306b\u4e88\u6e2c\u3059\u308b\u624b\u6cd5\u3092\u958b\u767a<\/span><\/strong><\/p><p class=\"wp-block-paragraph\"><span data-fontSize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u4e2d\u67a2\u75be\u60a3\u6cbb\u7642\u85ac\u306e\u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3051\u308b\u6210\u529f\u78ba\u7387\u306f\u3001\u4f9d\u7136\u3068\u3057\u3066\u975e\u5e38\u306b\u4f4e\u3044\u3067\u3059\u3002\u524d\u81e8\u5e8a\u8a66\u9a13\uff08\u5b9f\u9a13\u52d5\u7269\uff09\u3092\u901a\u904e\u3057\u305f\u5019\u88dc\u54c1\u306e\u591a\u304f\u304c\u3001\u30d2\u30c8\u3067\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u5931\u6557\u3059\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e3b\u8981\u306a\u8981\u56e0\u306e\u4e00\u3064\u304c\u3001\u5019\u88dc\u54c1\u304c\u3001\u30d2\u30c8\u306e\u8840\u6db2\u8133\u95a2\u9580\u3092\u901a\u904e\u3057\u306a\u3044\u3001\u3042\u308b\u3044\u306f\u901a\u904e\u3057\u3059\u304e\u3066\u526f\u4f5c\u7528\u3092\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u3052\u3089\u308c\u307e\u3059\u3002\u6211\u3005\u306f\u3001\u6a19\u7684\u7d76\u5bfe\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\uff08quantitative Targeted Absolute Proteomics, qTAP\u6cd5\uff09\u3092\u7528\u3044\u3066\u3001\u30d2\u30c8\u3068\u5b9f\u9a13\u52d5\u7269\u306e\u9593\u3067\u306f\u3001\u8840\u6db2\u8133\u95a2\u9580\u306e\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3084\u53d7\u5bb9\u4f53\u5206\u5b50\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u7d76\u5bfe\u767a\u73fe\u91cf\u306b\u5927\u304d\u306a\u9055\u3044\u304c\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3001\u5b9f\u9a13\u52d5\u7269\u3068\u30d2\u30c8\u306e\u85ac\u7269\u8133\u79fb\u884c\u6027\u306e\u7a2e\u5dee\u306e\u539f\u56e0\u3092\u89e3\u660e\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u3001\u3052\u3063\u6b6f\u985e\u3067\u306f\u3001P\u7cd6\u30bf\u30f3\u30d1\u30af\uff08P-gp\uff09\u304c\u6700\u3082\u9ad8\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u85ac\u7269\u306e\u8133\u3078\u306e\u79fb\u884c\u6027\u3092\u5236\u9650\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u30d2\u30c8\u3067\u306f\u3001P-gp\u3088\u308a\u3082\u3001Breast Cancer Resistance Protein\uff08BCRP\uff09\u3068\u3044\u3046\u5225\u306e\u6392\u51fa\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u304c\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u5f93\u3063\u3066\u3001\u65b0\u85ac\u958b\u767a\u306b\u304a\u3044\u3066\u3001\u3052\u3063\u6b6f\u985e\u3067\u5f97\u3089\u308c\u305f\u85ac\u7269\u8133\u79fb\u884c\u6027\u306e\u30c7\u30fc\u30bf\u306f\u3001\u5fc5\u305a\u3057\u3082\u30d2\u30c8\u306e\u8133\u79fb\u884c\u6027\u4e88\u6e2c\u306b\u9069\u7528\u3067\u304d\u306a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/span><\/p><p class=\"wp-block-paragraph\"><span data-fontSize=\"18px\" style=\"font-size: 18px;\" class=\"vk_inline-font-size\">\u305d\u3053\u3067\u3001\u6211\u3005\u306f\u3001\u30d2\u30c8\u306e\u85ac\u7269\u8133\u79fb\u884c\u6027\u3092\u4e88\u6e2c\u3059\u308b\u305f\u3081\u306b\u3001\u30d2\u30c8\u8840\u6db2\u8133\u95a2\u9580\u306e\u8f38\u9001\u30b7\u30b9\u30c6\u30e0\u3092\u8981\u7d20\u306b\u5206\u89e3\u3057\u3001\u5404\u8981\u7d20\u3092\u5b9f\u9a13\u3067\u6e2c\u5b9a\u3057\u3001\u518d\u5ea6\u3001\u69cb\u7bc9\u3057\u306a\u304a\u3059\u3053\u3068\u306b\u3088\u3063\u3066\u7406\u89e3\u3059\u308b\u6226\u7565\u3092\u3068\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u300c\u518d\u69cb\u7bc9\u300d\u6226\u7565\u306b\u3088\u3063\u3066\u3001P-gp\u306b\u8f38\u9001\u3055\u308c\u308b\u57fa\u8cea\u85ac\u7269\u306e\u8133\u79fb\u884c\u6027\u3092\u6b63\u78ba\u306b\u4e88\u6e2c\u3067\u304d\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u30d2\u30c8\u306b\u985e\u4f3c\u3057\u3066\u3044\u308b\u30ab\u30cb\u30af\u30a4\u30b6\u30eb\u3067\u5b9f\u8a3c\u3067\u304d\u305f\u3053\u3068\u3001\u3055\u3089\u306b\u75c5\u614b\u6642\u3067\u3082\u5b9f\u8a3c\u3067\u304d\u305f\u3053\u3068\u304b\u3089\u3001\u30d2\u30c8\u3001\u75c5\u614b\u306b\u304a\u3051\u308b\u85ac\u7269\u306e\u8133\u79fb\u884c\u6027\u4e88\u6e2c\u306b\u7a81\u7834\u53e3\u3092\u62d3\u304f\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/span><\/p><div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\"><div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1007\" height=\"754\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research5.png\" alt=\"\" class=\"wp-image-849\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research5.png 1007w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research5-300x225.png 300w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research5-768x575.png 768w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research5-500x374.png 500w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research5-800x599.png 800w\" sizes=\"auto, (max-width: 1007px) 100vw, 1007px\" \/><\/figure><\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1013\" height=\"761\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research6.png\" alt=\"\" class=\"wp-image-850\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research6.png 1013w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research6-300x225.png 300w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research6-768x577.png 768w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research6-500x376.png 500w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research6-800x601.png 800w\" sizes=\"auto, (max-width: 1013px) 100vw, 1013px\" \/><\/figure><\/div><\/div><div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\"><div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1013\" height=\"723\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research7.png\" alt=\"\" class=\"wp-image-851\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research7.png 1013w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research7-300x214.png 300w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research7-768x548.png 768w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research7-500x357.png 500w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research7-800x571.png 800w\" sizes=\"auto, (max-width: 1013px) 100vw, 1013px\" \/><\/figure><\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1007\" height=\"756\" src=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research8.png\" alt=\"\" class=\"wp-image-852\" srcset=\"https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research8.png 1007w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research8-300x225.png 300w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research8-768x577.png 768w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research8-500x375.png 500w, https:\/\/uchidalab.hiroshima-u.ac.jp\/wp-content\/uploads\/2024\/11\/Research8-800x601.png 800w\" sizes=\"auto, (max-width: 1007px) 100vw, 1007px\" \/><\/figure><\/div><\/div><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><\/p><p class=\"wp-block-paragraph\"><\/p><p 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