English

業績

2025年度

原著論文

  1. Furuta T, Miyoshi H, Moritsubo M, Nakajima R, Negoto T, Nakamura H, Morioka M, Uchida Y, Ohtsuki S, Nakada M. Biological role and clinicopathological significance of leucine-rich α-2 glycoprotein 1 in the glioblastoma microenvironment. J Neuropathol Exp Neurol(IF=3.0). 2025 Aug 1;84(8):707-714. doi: 10.1093/jnen/nlaf049. PMID: 40341932.
  2. Garaeva F, Nakajima R, Tamai S, Tateishi K, Mukasa A, Kawabata S, Nagashima H, Natsumeda M, Hirai N, Tanaka S, Ohba S, Higa N, Arakawa Y, Kondo A, Kohzuki H, Koizumi S, Fujioka Y, Abe T, Sabit H, Kinoshita M, Uchida Y, Ohtsuki S, Nakada M.Ataxin-2 as a candidate blood biomarker for estimating disease status in cases of suspected glioblastoma recurrence. Brain Tumor Pathol(IF=3.0). 2025 Sep 22. doi: 10.1007/s10014-025-00517-z. Epub ahead of print. PMID: 40982134.
  3. Inoue S, Shirakura K, Shirono A, Taguchi J, Ikeda Y, Tomita S, Funatsu R, Muraoka K, Hashimoto Y, Tachibana K, Hino N, Doi T, Ikemi Y, Nunomura K, Lin B, Nakagawa S, Tsujikawa K, Tanaka S, Obana M, Fujio Y, Hosoya T, Takeda H, Kondoh M, Okada Y. Claudin 5-binding small molecule transiently opens the blood-brain barrier and safely enhances brain drug delivery. J Control Release(IF=11.5). 2025 Dec 10;388(Pt 1):114314. doi:10.1016/j.jconrel.2025.114314. PMID: 41083006.
  4. Akiyoshi T, Tonduru AK, Kataoka H, Morita T, Yajima K, Imaoka A, Katayama K, Medarametla P, Uchida Y, Poso A, Ohtani H, Terasaki T. Stoichiometric transport of estrone 3-sulfate among genetic variants of OATP1A2 and OATP2B1 and structural analysis by molecular dynamics simulation: Impairment of gating mechanism in the unstable inward-open conformation of OATP2B1 (Asp215Val) significantly suppress the transport activity. Drug Metab Dispos.(IF=4.0) 2025 Dec;53(12):100198. doi: 10.1016/j.dmd.2025.100198. Epub 2025 Nov 5. PMID: 41349357.
  5. Masashi Kawami, Yutaka Takeuchi, Kosuke Fuji, Ryoko Yumoto, Mikihisa Takano, Yasuo Uchida. Reprogramming of Alveolar Macrophages by the Bacterial Peptide iEDAP via PEPT2 Transport. Toxicological Research(IF=2.3), Accepted for publication.
  6. Wagatsuma T, Yamamoto A, Nishimura Y, Kawami M, Ito J, Hirayama T, Masuda S, Nakagawa K, Uchida Y, Kambe T. Zinc-MTF1-metallothionein axis plays critical roles in the defense against ferroptosis in human cells. Free Radic Biol Med.(IF=8.2) 2026 Jan 5:S0891-5849(26)00008-0. doi: 10.1016/j.freeradbiomed.2026.01.008. Epub ahead of print. PMID: 41500342.
  7. Kawami Masashi, Takeuchi Yutaka, Fuji Kosuke, Yumoto, Ryoko, Takano Mikihisa, Uchida, Yasuo, Inflammatory reprogramming of alveolar macrophages by the bacterial peptide iE-DAP via PEPT2 transport Toxicological Research, 2026, DOI:10.1007/s43188-025-00335-7

総説論文

  1. Yosuke Hashimoto, Yuki Maeda, Matthew Campbell, Yasuo Uchida. Transcellular transport at the blood-brain barriers in health and disease. Membrane Transporters and Drug Delivery: a comprehensive and multidisciplinary guide, Elsevier, Accepted for publication

2024年度

原著論文

  1. Hamano S, Noguchi T, Asai Y, Ito R, Komatsu R, Sato T, Inoue A, Maruyama T, Kudo TA, Hirata Y, Shindo S, Uchida Y, Hwang GW, Matsuzawa A. Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos. Cell Death Discov. 2024 Feb 12;10(1):74. doi: 10.1038/s41420-024-01838-2. PMID: 38346947; PMCID: PMC10861449.
  2. Arime Y, Saitoh Y, Ishikawa M, Kamiyoshihara C, Uchida Y, Fujii K, Takao K, Akiyama K, Ohkawa N. Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia. Neuropsychopharmacology. 2024 Mar;49(4):720-730. doi: 10.1038/s41386-023-01769-z. Epub 2023 Dec 4. PMID: 38049583; PMCID: PMC10876596.
  3. Kataoka H, Akiyoshi T, Uchida Y, Imaoka A, Terasaki T, Ohtani H. The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1. J Pharm Sci. 2024 May;113(5):1376-1384. doi: 10.1016/j.xphs.2024.02.012. Epub 2024 Mar 1. PMID: 38432624.
  4. Yuasa H, Morino N, Wagatsuma T, Munekane M, Ueda S, Matsunaga M, Uchida Y, Katayama T, Katoh T, Kambe T. ZNT5-6 and ZNT7 play an integral role in protein N-glycosylation by supplying Zn2+ to Golgi α-mannosidase II. J Biol Chem. 2024 Jun;300(6):107378. doi: 10.1016/j.jbc.2024.107378. Epub 2024 May 16. PMID: 38762179; PMCID: PMC11209640.
  5. Ramsay E, Montaser AB, Niitsu K, Urtti A, Auriola S, Huttunen KM, Uchida Y, Kidron H, Terasaki T. Transporter Protein Expression of Corneal Epithelium in Rabbit and Porcine: Evaluation of Models for Ocular Drug Transport Study. Mol Pharm. 2024 Jul 1;21(7):3204-3217. doi: 10.1021/acs.molpharmaceut.3c01210. Epub 2024 May 29. PMID: 38809137.
  6. Yoshimori T, Kawami M, Kumagai Y, Futatsugi S, Yumoto R, Uchida Y, Takano M. Abemaciclib-induced epithelial-mesenchymal transition mediated by cyclin-dependent kinase 4/6 independent of cell cycle arrest pathway. Int J Biochem Cell Biol. 2024 Jul;172:106601. doi: 10.1016/j.biocel.2024.106601. Epub 2024 May 29. PMID: 38821314.
  7. Hashimoto Y, Besmond C, Boddaert N, Munnich A, Campbell M. A loss of function mutation in CLDN25 causing Pelizaeus-Merzbacher-like leukodystrophy. Hum Mol Genet. 2024 Jun 5;33(12):1055-1063. doi: 10.1093/hmg/ddae038. PMID: 38493358; PMCID: PMC11153337.
  8. Hashimoto Y, Greene C, Hanley N, Hudson N, Henshall D, Sweeney KJ, O’Brien DF, Campbell M. Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier. Fluids Barriers CNS. 2024 Jun 19;21(1):52. doi: 10.1186/s12987-024-00553-5. PMID: 38898501; PMCID: PMC11188261.
  9. Akai M, Maeda Y, Kawami M, Yumoto R, Takano M, Uchida Y. miR-PAIR: microRNA-protein analysis of integrative relationship for the identification of significantly working miRNAs. Biochim Biophys Acta Gen Subj. 2025 Feb;1869(2):130746. doi: 10.1016/j.bbagen.2024.130746. Epub 2024 Dec 18. PMID: 39706375.
  10. Avril Reddy, Chris Greene, Yosuke Hashimoto, Anna-Sophia Kiang, Natalie Hudson, Peter Adamson, Tiago Santos-Ferreira, Matthew Campbell. Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease. Mol. Ther. Methods Clin. Dev., 33(2):101450 (June, 2025). doi: 10.1016/j.omtm.2025.101450

総説

  1. 前田祐希、川見昌史、内田康雄、血液クモ膜関門：血液脳関門とは異なる輸送分子機構をもつ新たな中枢関門、膜、49巻2号、p99-106、2024年
  2. 赤井美月、川見昌史、内田康雄、SWATH-MS法を利用した金属輸送体の機能解析、生体の科学、75巻2号、p116-121、2024年
  3. <Preview> Hashimoto Y, Campbell M. Eyes on glutamate in angiogenesis and barrier formation. Neuron. 2024 Jun 19;112(12):1895-1897. doi: 10.1016/j.neuron.2024.05.020. PMID: 38901398.

2023年度

原著論文

  1. Iio K, Hashimoto K, Nagumo Y, Amezawa M, Hasegawa T, Yamamoto N, Kutsumura N, Takeuchi K, Ishikawa Y, Yamamoto H, Tokuda A, Sato T, Uchida Y, Inoue A, Tanimura R, Yanagisawa M, Nagase H, Saitoh T. Design and Synthesis of Orexin 1 Receptor-Selective Agonists. J Med Chem. 2023 Apr 27;66(8):5453-5464. doi: 10.1021/acs.jmedchem.2c01773. Epub 2023 Apr 12. PMID: 37043436.
  2. Ishiguro H, Mizuno T, Uchida Y, Sato R, Sasaki H, Nemoto S, Terasaki T, Kusuhara H. Characterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH method. NAR Genom Bioinform. 2023 Mar 11;5(1):lqad022. doi: 10.1093/nargab/lqad022. PMID: 36915410; PMCID: PMC10006730.
  3. Wang Y, Sakaguchi M, Sabit H, Tamai S, Ichinose T, Tanaka S, Kinoshita M, Uchida Y, Ohtsuki S, Nakada M. COL1A2 inhibition suppresses glioblastoma cell proliferation and invasion. J Neurosurg. 2022 Aug 5;138(3):639-648. doi: 10.3171/2022.6.JNS22319. PMID: 35932265.

総説

  1. 内田康雄、次世代型定量プロテオミクスによる中枢関門トランスポーター研究、薬剤学、83巻2号、p72-77、2023年